alexa Cytoskeleton and CRMPs in Neuronal Morphogenesis and Neurological Diseases: Potential Targets for New Therapies
ISSN: 2329-6895

Journal of Neurological Disorders
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Review Article

Cytoskeleton and CRMPs in Neuronal Morphogenesis and Neurological Diseases: Potential Targets for New Therapies

Quach TT1,2, Auvergnon N1, Lerch J2, Honnorat J1,3,4, Khanna R5, Kolattukudy PE6 and Duchemin AM7*
1Lyon Neuroscience Research Center INSERM U1028/CNRS UMR 5292, F-69372 Lyon, France
2Department of Neuroscience, Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, OH, 43210, USA
3French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, Neurologie B, F-69677 Bron, France
4Université de Lyon - Université Claude Bernard Lyon 1, F-69372 Lyon, France
5Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ, 85724. USA
6Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL,32816, USA
7Department of Psychiatry, College of Medicine, The Ohio State University. Columbus, OH, 43210, USA
*Corresponding Author : Duchemin AM
Department of Psychiatry
College of Medicine, The Ohio State
University, Columbus, OH, 43210, USA
Tel: (614) 293-4540
Email: [email protected]
Received: January 01, 2016 Accepted: January 12, 2015 Published: January 25, 2016
Citation: Quach TT, Auvergnon N, Lerch J, Honnorat J, Khanna R, et al. (2016) Cytoskeleton and CRMPs in Neuronal Morphogenesis and Neurological Diseases: Potential Targets for New Therapies. J Neurol Disord 4:257. doi:10.4172/2329-6895.1000257
Copyright: © 2016 Quach TT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Cytoskeletal proteins, and the molecules that control their assembly/disassembly, regulate neurite and spine growth and retraction, which are necessary for normal brain function. The neuron begins as a spherical shape, then lamellipodia and filopodia form nascent neurites which differentiate into dendrites and axons. These processes, also involved in neuronal plasticity, require changes in the dynamics of the cytoskeleton proteins and their intracellular binding partners, including collapsin-response mediator proteins (CRMPs). Abnormal changes in CRMP signaling induce structural/ functional abnormalities in neurons which are characteristics of various neurological disorders. Modulation of these pathways may represent unexplored areas for treatment of these diseases.

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