Cytotoxic Effects of Lysimachia ramosa Wall. Ex Duby (Primulaceae) on Swiss Albino MiceBishnupada Roy* and Paulomi Dey
Department of Zoology, North-Eastern Hill University, Shillong, India
- Corresponding Author:
- Bishnupada Roy
Department of Zoology, North- Eastern Hill University, Shillong 793 022, India
E-mail: [email protected]
Received Date: November 01, 2016; Accepted Date: November 25, 2016; Published Date: November 29, 2016
Citation: Roy B, Dey P (2016) Cytotoxic Effects of Lysimachia ramosa Wall. Ex Duby (Primulaceae) on Swiss Albino Mice. J Pharmacogn Nat Prod 2:126. doi: 10.4172/2472-0992.1000126
Copyright: © 2016 Roy B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Lysimachia ramosa is a traditional medicinal plant, consumed by different tribes of northeast India to cure intestinal helminth infections. In order to measure the toxic effects of the plant on its consumer, if any, the present in vivo study was carried out on mice using sub-lethal doses of crude ethanol extract viz. 100 and 200 mg/kg body weight for 14 days. Surface topographical and ultrastructural observations on liver, kidney and intestine of treated mice revealed marked deformation and destruction accompanied by quantitative changes in liver and kidney markers like aspartate aminotransferase, alanine aminotransferase and creatinine in comparison to the control mice. The results showed that consumption of crude plant extract at a dose 100 mg and above per kg body weight continuously for long time may cause toxic effects to its consumer.