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Cytotoxicity and Reactive Oxygen Species Generated by Ferrocenium and Ferrocene on MCF7 and MCF10A Cell Lines | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Research Article

Cytotoxicity and Reactive Oxygen Species Generated by Ferrocenium and Ferrocene on MCF7 and MCF10A Cell Lines

Claudia Y Acevedo-Morantes1, Enrique Meléndez2, Surinder P Singh1 and Jaime E Ramírez-Vick1*

1Engineering Science & Materials Department, University of Puerto Rico, P.O. Box 9000, Mayaguez, PR 00681, USA

2Department of Chemistry, University of Puerto Rico, P.O. Box 9000, Mayaguez, PR 00681, USA

*Corresponding Author:
Jaime E. Ramírez-Vick
Engineering Science & Materials Department
University of Puerto Rico, P.O. Box 9000
Mayaguez, PR 00681, USA
E-mail: [email protected]

Received date: July 02, 2012; Accepted date: August 16, 2012; Published date: August 18, 2012

Citation: Acevedo-Morantes CY, Meléndez E, Singh SP, Ramírez-Vick JE (2012) Cytotoxicity and Reactive Oxygen Species Generated by Ferrocenium and Ferrocene on MCF7 and MCF10A Cell Lines. J Cancer Sci Ther 4:271-275. doi:10.4172/1948-5956.1000154

Copyright: © 2012 Acevedo-Morantes CY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The aim of this study was to investigate the effect of ferrocene (FeCp2) and ferrocenium salt (FeCp2BF4) on the viability of MCF7 breast cancer and MCF10A non-tumorigenic epithelial cells and the role of Reactive Oxygen Species (ROS) production in cell cytotoxicity. FeCp2BF4 displayed higher cytotoxicity than FeCp2, and the cell type contributes toward complexes toxicity, as MCF7 cells displays greater toxicity than MCF10A cells. The mechanism of toxicity seems to involve the generation of ROS, with MCF7 cells producing higher levels than epithelial cells. In addition, the inhibition of ROS was found to be protective against ferrocene induced cell death. The findings of cancerous cell-induced cytotoxicity by ROS indicate a potential utility of ferrocenyl derivatives in the treatment of cancer.

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