alexa Cytotoxicity of Chitosan Oligomers Produced by Crude En
ISSN: 2155-9821

Journal of Bioprocessing & Biotechniques
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Research Article

Cytotoxicity of Chitosan Oligomers Produced by Crude Enzyme Extract from the Fungus Metarhizium Anisopliae in Hepg2 and Hela Cells

Cristiane Fernandes de Assis1, Raniere Fagundes Melo-Silveira2, Ruth Medeiros de Oliveira2, Leandro Silva Costa2, Hugo Alexandre de Oliveira Rocha2, Gorete Ribeiro de Macedo1* and Everaldo Silvino dos Santos1
1Department of Chemical Engineering, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
2Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
Corresponding Author : Gorete Ribeiro de Macedo
Departamento de Engenharia Química
Centro de Tecnologia, Av. Senador Salgado Filho, s/n
Lagoa Nova, 50072-970 ,NATAL - Rio Grande do Norte, Brazil
Tel: 55-84-3215-3769
Fax: 55- 84-3215-3770
E-mail: [email protected]
Received October 17, 2011; Accepted February 10, 2012; Published February 13, 2012
Citation: de Assis CF, Melo-Silveira RF, de Oliveira RM, Costa LS, de Oliveira Rocha HA, et al. (2012) Cytotoxicity of Chitosan Oligomers Produced by Crude Enzyme Extract from the Fungus Metarhizium Anisopliae in Hepg2 and Hela Cells. Bioprocess Biotechniq 2:114. doi: 10.4172/2155-9821.1000114
Copyright: © 2012 de Assis CF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Chitooligosaccharides exhibit biological activities, including antitumor, antimicrobial and antioxidant. In this study we used a mixture of chitooligosaccharides produced by enzymatic hydrolysis in two tumor cell lines and assessed the cell proliferation and cytotoxicity of these compounds. The proliferation of HeLa cells was inhibited around by 60%. 

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