alexa Cytotoxicity of Heavy Metals to A Thyroid Carcinoma Cel
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
Open Access

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Short Communication

Cytotoxicity of Heavy Metals to A Thyroid Carcinoma Cell Line

Jun Kobayashi1*, Keiichi Ikeda2 and Hideo Sugiyama3

1Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan

2Faculty of Pharmaceutical Sciences, Hokuriku University, Ishikawa, Japan

3Graduate School of Health Sciences, Matsumoto University, Nagano, Japan

*Corresponding Author:
Jun Kobayashi
School of Veterinary Nursing and Technology, Faculty of Veterinary Medicine
Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
Tel: +81422314151
Fax: +81422332094
E-mail: [email protected]

Received Date: March 21, 2017; Accepted Date: April 26, 2017; Published Date: April 29, 2017

Citation: Kobayashi J, Ikeda K, Sugiyama H (2017) Cytotoxicity of Heavy Metals to A Thyroid Carcinoma Cell Line. J Environ Anal Toxicol 7:461. doi: 10.4172/2161- 0525.1000461

Copyright: © 2017 Kobayashi J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Multiple heavy metals are known to cause renal insufficiency and necrosis, details on the toxic mechanism are still lacking. We investigated the cytotoxicity of 12 heavy metals to the 8505C thyroid cancer cells at concentrations of 10−3–105 μM. Notable decreases in cell viability were observed in exposures to four metals in the divalent cation form (nickel, copper, zinc, and cadmium) at concentrations ≥ 1 μM. The effect of cadmium on cell death was substantial. In addition, the toxicity of 3 μM cadmium to the cells was inhibited by the addition of high concentrations (300 μM) of calcium or selenium, but intracellular levels of cadmium increased.


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