alexa Danely P.Slaughters Field Cancerization Concept of Carcinogenesis: The Path Forward to Early Cancer Detection and Chemoprevention | OMICS International | Abstract
ISSN: 2168-9296

Cell & Developmental Biology
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Research Article

Danely P.Slaughters Field Cancerization Concept of Carcinogenesis: The Path Forward to Early Cancer Detection and Chemoprevention

Gabriel D. Dakubo1,2*
1Xavier University School of Medicine, Santa Helenastrat #23, Aruba, Oranjestad, Kingdom of the Netherlands.
2Northern Ontario School of Medicine, Lakehead University Campus, 955 Oliver Road, Thunder Bay Ontario, Canada, P7B 5E1
Corresponding Author : Gabriel D. Dakubo
Xavier University School of Medicine
Santa Helenastrat #23, Aruba
Oranjestad, Kingdom of the Netherlands
Tel: 297-588-7766
Fax: 297-588-6222
E-mail: [email protected]
Received: May 10, 2015 Accepted: August 18, 2015 Published: August 24, 2015
Citation: Gabriel Dakubo D (2015) Danely P. Slaughter’s Field Cancerization Concept of Carcinogenesis: The Path Forward to Early Cancer Detection and Chemoprevention. Cell Dev Biol 4:158. doi:10.4172/2168-9296.1000158
Copyright: © 2015 Dakubo GD. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

It is over seven decades since the seminal work of the otolaryngologist, Dr. Danely Slaughter was published. In patients with oral cancer, he critically demonstrated that carcinogen exposure led to the development of “condemned mucosa”, within which multiple cancers emanated. Thus, the histologically normal cells adjacent to the primary tumor harbor invisible features of the cancer. Other workers such as Strong have confirmed Slaughter’s initial observations, and in recent times by many investigators using molecular genetic approaches. This concept of carcinogenesis is partly responsible for our failure to successfully treat some of our cancer patients. With current technological advancements, biomarkers of field cancerization can be assayed using even noninvasive samples such as body fluids such as saliva and bronchial washes. In clinical practice, such validated biomarkers should enable risk stratification, and hence close surveillance of individuals at risk for early cancer detection or the early deployment of chemopreventive strategies. Arguably, this will immensely contribute to the reduction in the socioeconomic, physical and psychological burden of cancer.

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