DAPK and P16 Methylation and HPV and EBV Infection in Small Cell Carcinoma of Cervix: A Case ReportFurtado YL1,2*, Lattario F2, Silveira FA1, Carvalho MGC3 and Almeida G1
- *Corresponding Author:
- Furtado YL
Instituto de Ginecologia da Universidade Federal do Rio de Janeiro (UFRJ), Brazil
Tel: +55 21 3938-9600
E-mail: [email protected]
Received March 05, 2016; Accepted April 21, 2016; Published April 26, 2016
Citation: Furtado YL, Lattario F, Silveira FA, Carvalho MGC, Almeida G (2016) DAPK and P16 Methylation and HPV and EBV Infection in Small Cell Carcinoma of Cervix: A Case Report. J Clin Case Rep 6:781. doi:10.4172/2165-7920.1000781
Copyright: © 2016 Furtado YL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Purpose: Small cell carcinoma (SMCC) of the cervix is rare and aggressive tumor, often diagnosed in an advanced stage and their prognosis is generally poor. A case of SMCC showing Human Papillomavirus (HPV) and Epstein barr virus (EBV) infection and Death-associated protein kinase (DAPK) and p16 genes methylation is presented. A 74-year-old woman was diagnosed as having stage IB2 of SMCC. Methods: HPV and EBV infection and DAPK and p16 gene methylation were found using molecular approaches. Results: The sample was positive for HPV and EBV infection and showed DAPK and p16 promoter regions methylated Conclusion: Methylation of DAPK and p16 gene could be used as a molecular marker in cervical cancer.