alexa DAPK and P16 Methylation and HPV and EBV Infection in Small Cell Carcinoma of Cervix: A Case Report
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

DAPK and P16 Methylation and HPV and EBV Infection in Small Cell Carcinoma of Cervix: A Case Report

Furtado YL1,2*, Lattario F2, Silveira FA1, Carvalho MGC3 and Almeida G1

1Instituto de Ginecologia da Universidade Federal do Rio de Janeiro (UFRJ), Brazil

2Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Brazil

3Departamento de Patologia, Laboratório de Patologia Molecular, Hospital Clementino Fraga Filho, UFRJ, Brazil

*Corresponding Author:
Furtado YL
Instituto de Ginecologia da Universidade Federal do Rio de Janeiro (UFRJ), Brazil
Tel: +55 21 3938-9600
E-mail: [email protected]

Received March 05, 2016; Accepted April 21, 2016; Published April 26, 2016

Citation: Furtado YL, Lattario F, Silveira FA, Carvalho MGC, Almeida G (2016) DAPK and P16 Methylation and HPV and EBV Infection in Small Cell Carcinoma of Cervix: A Case Report. J Clin Case Rep 6:781. doi:10.4172/2165-7920.1000781

Copyright: © 2016 Furtado YL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

 

Purpose: Small cell carcinoma (SMCC) of the cervix is rare and aggressive tumor, often diagnosed in an advanced stage and their prognosis is generally poor. A case of SMCC showing Human Papillomavirus (HPV) and Epstein barr virus (EBV) infection and Death-associated protein kinase (DAPK) and p16 genes methylation is presented. A 74-year-old woman was diagnosed as having stage IB2 of SMCC. Methods: HPV and EBV infection and DAPK and p16 gene methylation were found using molecular approaches. Results: The sample was positive for HPV and EBV infection and showed DAPK and p16 promoter regions methylated Conclusion: Methylation of DAPK and p16 gene could be used as a molecular marker in cervical cancer.

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