Data Mined Distinctive Features of Pediatric Chronic Idiopathic Intestinal Pseudo-obstruction in Japan
Mitsuru Muto*, Hiroshi Matsufuji, Fuminori Muranaga, Takeshi Tomomasa, Atsushi Nakajima and Tomoaki Taguchi
Department of Pediatric Surgery, Kagoshima University, Japan
- *Corresponding Author:
- Mitsuru Muto
Department of Pediatric Surgery
Kagoshima University, 8-35-1 Sakuragaoka
Kagoshima, 890-8520, Japan
Tel: +81 99 275 5444
Fax: +81 99 275 2628
E-mail: [email protected]
Received Date: February 04, 2015; Accepted Date: March 05, 2015; Published Date: March 09, 2015
Citation: Muto M, Matsufuji H, Muranaga F, Tomomasa T, Nakajima A, et al. (2015) Data Mined Distinctive Features of Pediatric Chronic Idiopathic Intestinal Pseudo-obstruction in Japan. Pediat Therapeut 5:236. doi:10.4172/2161-0665.1000236
Copyright: © 2015 Muto M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: A former nationwide survey in Japan on pediatric chronic intestinal pseudo-obstruction (CIPO) determined the most common etiology to be 'idiopathic'. However, currently no appropriate diagnostic criteria for pediatric chronic idiopathic intestinal pseudo-obstruction (CIIP) in children has been defined. The report utilized data mining to identify key clinical features that would qualify statistically CIIP diagnostic criteria.
Methods: Sixty-nine cases were reviewed and subject to standard mining association rule. Cases were assigned to three groups: fully dependent on parenteral nutrition (PN) (group A, n = 15), on partial PN or independent from PN, but requiring permanent enterostomy for decompression (group B, n = 37), and all the other (group C, n = 17). Distinctive features related to each group assignment were then extracted from 87 reported clinical features of the CIPO. The statistical operation was performed by an expert in medical informatics using apriori algorithm. Results: Key features of patients in group A and B, thought to be severely intractable cases, were the presence of abdominal distension, intestinal dysmotility, ileus without mechanical obstruction, and the absence of histopathological abnormalities in the intramural ganglion cells. Conclusions: The presence of clinical features of a functional ileus, in the absence of proven histopathological abnormalities, can be used for diagnostic criteria for CIIP covering all the intractable cases in Japanese children. It is highly significant that a normal full-thickness histopathological finding was statistically extracted as one key feature for CIIP in our analysis.