alexa Day 4 Biopsy Improves Pregnancy Outcome Comparing to Day 3 Biopsy in Preimplantation Genetic Screening | OMICS International | Abstract
ISSN: 2161-0932

Gynecology & Obstetrics
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Day 4 Biopsy Improves Pregnancy Outcome Comparing to Day 3 Biopsy in Preimplantation Genetic Screening

Eun-Kyung Kim1, Eun-Ah Kim1, Eun-Ha Kim1, Nam-Hyung Kim2, Dong-Hee Choi1,3 and Hwang Kwon1,3*

1Fertility Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea

2Department of Animal Science, Chungbuk National University, Chungju, Chungbuk

3Department of Obstetrics and Gynecology, CHA University, Seongnam, Korea

*Corresponding Author:
Hwang Kwon
Fertility Center, CHA Bundang Medical Center
CHA University, Seongnam-si, 463-712, Korea
Tel: +82-31-780-5871
E-mail: [email protected]

Received date: September 02, 2015; Accepted date: October 16, 2015; Published date: October 25, 2015

Citation: Kim EK, Kim EA, Kim EH, Kim NH, Choi DH, et al. (2015) Day 4 Biopsy Improves Pregnancy Outcome Comparing to Day 3 Biopsy in Preimplantation Genetic Screening. Gynecol Obstet (Sunnyvale) 5:330. doi:10.4172/2161-0932.1000330

Copyright: © 2015 Kim EK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Aim: Preimplantation genetic screening (PGS) is a routine procedure performed in many in vitro fertilization (IVF) clinics. Embryo biopsy is an invasive procedure, and it has long been recognised that this procedure can affect the subsequent growth and development of the embryo.

Materials and methods: In total, 38 cycles from 31 couples were included in this study. Day 3 biopsy was performed on 126 embryos of 18 patients; 20 patients chose day 4 biopsy with 150 embryos tested. All specimens were screened on a 24-chromosome comparative genomic hybridization (CGH) array.

Results: Of the embryos subjected to day 3 and day 4 biopsies, 22.2% (28/126) and 28.7% (43/150) were normal, demonstrating that our biopsy system has no obvious detrimental effect on compaction. Embryos were transferred on the mornings of day 4 and day 5. Compared with day 3 biopsy (4/13; 30.8%), the day 4 biopsy (7/16; 43.8%) procedure provides an improved pregnancy rate with embryo transfer in current IVF cycle.

Conclusions: We suggest that biopsy performance on day 4, to obtain genetic materials without compromising embryo viability, shows promise for successful PGS in IVF.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7