alexa Deaths from Twin-Twin Transfusion Syndrome in Japan, 1995?2008
ISSN: 2161-0932

Gynecology & Obstetrics
Open Access

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Research Article

Deaths from Twin-Twin Transfusion Syndrome in Japan, 1995?2008

Y. Imaizumi* and K. Hayakawa

Department of Health Sciences, Graduate School of Medicine, Osaka University, Suita City, Japan

*Corresponding Author:
Dr. Y. Imaizumi
Department of Health Sciences
Graduate School of Medicine
Osaka University, Suita City, Japan
E-mail: [email protected]

Received date: February 24, 2012; Accepted date: March 15, 2012; Published date: March 20, 2012

Citation: Imaizumi Y, Hayakawa K (2012) Deaths from Twin-Twin Transfusion Syndrome in Japan, 1995–2008. Gynecol Obstetric 2:116. doi:10.4172/2161-0932.1000116

Copyright: © 2012 Imaizumi Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: To estimate rates of fetal death, perinatal mortality, and infant mortality as well as the prevalence, concordance rates, and birth weight discordance attributed to twin-twin transfusion syndrome (TTTS). Study design: These rates were estimated using Japanese Vital Statistics from 1995 to 2008. The total number of one or both members of a twin pair with TTTS was 1102. Results: During 1999 and 2000, fetal death and perinatal and infant mortality rates related to TTTS decreased (48 per 10,000 births, 44 per 10,000 live births and fetal deaths after 22 weeks of gestation, and 16 per 10,000 live births, respectively) compared with those during 2007 and 2008 (31, 21 and 7, respectively). The fetal death rate was higher in male than in female fetuses. Furthermore, fetal death and infant mortality rates were the highest during gestational weeks 22–25; these rates decreased with gestational age and reached their lowest values at ≥38 weeks. Frequency of birth weight discordance ≥15% was 82% among all subjects. The concordance rate was 44% (484/1102 pairs of twins), whereas the overall prevalence was 1.1 per 100 monozygotic twin pairs from 1995 through 2008. Conclusion: Fetal death and infant mortality rates decreased with maternal age. The declining rates of fetal death and perinatal and infant mortality related to TTTS may be related to recent improvements in medical treatments for TTTS in Japan.


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