Decreased Protein C Levels in Endomyocardial Fibrosis: The Possible SignificancePrabha Nini Gupta*, Kumaralingam G Balakrishnan and Kartha CC
ICMR Centre for Research in Cardiomyopathies, Sri Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India
- *Corresponding Author:
- Prabha Nini Gupta
ICMR Centre for Research in Cardiomyopathies
Sri Chitra Tirunal Institute for Medical Sciences and Technology
T/C 5/2091, Near the Sri Krishna Temple, Cheruvekkal
Srikaryam, Trivandrum-695017, Kerala, India
E-mail: [email protected]
Received date: September 24, 2013; Accepted date: October 31, 2013; Published date: November 03, 2013
Citation: Gupta PN, Balakrishnan KG, Kartha CC (2013) Decreased Protein C Levels in Endomyocardial Fibrosis: The Possible Significance. J Blood Disord Transfus 4:170.doi: 10.4172/2155-9864.1000170
Copyright: © 2013 Gupta PN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The occurrence of frequent intracardiac thrombi in Endomyocardial fibrosis, and the embolization of these thrombi contributing to the morbidity is an established fact. Since previous studies on endomyocardial fibrosis revealed normal prothrombin time, clotting times, bleeding time, it was considered worthwhile to investigate whether an inherited deficiency of protein C contributed to thrombosis in these patients. Measurements of protein C functional levels revealed that 17/18 (94.4%) of patients tested and 4/18 of the healthy controls were functionally deficient (p<.001) while the antigenic levels of 7 patients and 3 controls were deficient. It was observed that 5.55% and 44.4% of patients had normal profiles and Type 1 deficiency respectively, while 44.4% had Type II deficiency. This association between protein C deficiency and endomyocardial fibrosis may contribute to the formation of intracardiac thrombi in these patients.