Decreased Serum Levels of Macrophage Derived Cytokine and Matrix Metalloproteinase-9 are associated with Disease Activity in the Patients with Systemic Lupus ErythematosusHamada S Ahmad1*, Gamal Othman2 and Sherief E Farrag1
- *Corresponding Author:
- Hamada S Ahmad
Rheumatology and Rehabilitation Department
Mansoura faculty of Medicine, Mansoura University, Egypt
E-mail: [email protected]
Received date: October 20, 2015; Accepted date: November 05, 2015; Published date: November 07, 2015
Citation: Ahmad HS, Othman G, Farrag SE (2015) Decreased Serum Levels of Macrophage Derived Cytokine and Matrix Metalloproteinase-9 are associated with Disease Activity in the Patients with Systemic Lupus Erythematosus. Rheumatology (Sunnyvale) 5:176. doi: 10.4172/2161-1149.1000176
Copyright: © 2015 Ahmad HS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aim: The aim of our study was to assess serum concentration of macrophage derived cytokine (MDC) and matrix metalloproteinase-9 (MMP-9) in patients with active and inactive SLE and in healthy volunteers.
Subjects and Methods: The study included 40 patients with SLE and 40 healthy control. The serum level of MDC and MMP-9 were evaluated and compared between the patients and the controls. The association of the MDC and MMP-9 with disease activity, renal involvement, drug intake were also evaluated.
Results: SLE patients had significantly lower MDC and lower MMP-9 than control (p<0.001). SLE patients who had nephritis had significantly lower MDC and lower MMP-9 than patients without nephritis (p=0.003, p=0.004 respectively). The lupus patients with +ve anti-dsDNA had significantly lower MMP-9 and MDC in their serum than patients with –ve anti-dsDNA (p=0.032, p=0.024 respectively). MDC and MMP-9 were inversely correlated with SLEDAI (p=0.008, p-0.003 respectively). No significant association was found between MDC and MMP- with disease duration or current drug intake.
Conclusion: These findings indicate that MDC and MMP-9 were involved in SLE pathogenesis, and MDC could be a marker for active SLE. Our findings indicated that MDC and MMP-9 seemed to be markers of renal involvement.