Special Issue Article
Defensins: More than Nature’s Anti-bug Spray?
|Erik de Leeuw*|
|Institute of Human Virology and Department of Biochemistry and Molecular Biology, Baltimore School of Medicine, University of Maryland, USA|
|Corresponding Author :||Erik de Leeuw
Institute of Human Virology and Department of Biochemistry
and Molecular Biology Baltimore School of Medicine
University of Maryland, USA
E-mail: [email protected]
|Received August 27, 2013; Accepted September 24, 2013; Published September 27, 2013|
|Citation: de Leeuw E (2013) Defensins: More than Nature’s Anti-bug Spray? J Bioanal Biomed S8:001. doi: 10.4172/1948-593X.S8-001|
|Copyright: © 2013 de Leeuw E. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Human defensins were originally identified as natural antimicrobial peptides that protect the host from infections. More recently, novel biological functions of these peptides have been described, expanding their role as natural antimicrobials. Here, our current understanding of this expanding role of human α-defensins is reviewed, with emphasis on antibacterial killing, bacterial toxin neutralization and immunity.