alexa Definition of Potential Targets in Mycoplasma Pneumoniae Through Subtractive Genome Analysis | OMICS International | Abstract
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
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Research Article

Definition of Potential Targets in Mycoplasma Pneumoniae Through Subtractive Genome Analysis

Gupta Sunil Kumar1, 2*, Singh Sarita1, 2, Gupta Manish Kumar3, Pant KK2, Seth PK1

1Bioinformatics Centre, Biotech Park, Sector-G, Jankipuram, Lucknow-226021, Uttar Pradesh, India

2Department of Pharmacology & Therapeutics, Chhatrapati Shahuji Maharaj Medical University, Chowk Lucknow-226003, Uttar Pradesh, India

3Department of Bioinformatics, University Institute of Engineering and technology, Chhatrapati Shahuji Maharaj University, Kanpur, India

*Corresponding Author:
Sunil Kumar Gupta,
Bioinformatics Centre, Biotech Park,
Sector-G, Jankipuram,
Lucknow-226021, Uttar Pradesh, India,
Fax: +91 522 4012081,
Tel: +91 522 4053010,
E-mail: [email protected]

Received Date: March 15, 2010; Accepted Date: April 26, 2010; Published Date: April 26, 2010

Citation: Gupta SK, Singh S, Gupta MK, Pant KK, Seth PK (2010) Definition of Potential Targets in Mycoplasma Pneumoniae Through Subtractive Genome Analysis. J Antivir & Antiretrovir 2: 038-041. doi: 10.4172/jaa.1000020

Copyright: © 2010 Gupta SK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Non-nucleoside reverse transcriptase inhibitor (NNRTI) -based antiretroviral therapy (ART) regimens have been recommended and widely used in resource-limited settings because of their reliable effi cacy, low pill burden, and low cost. This study sought to determine outcomes and toxicities of NNRTI-based ART over a period of 208 weeks. A total of 244 HIV/AIDS Thai patients with a mean (±SD) age of 36 (±8.1) years initiated NNRTI-based ART in 2004. The median (inter-quartile range) baseline CD4 cell counts and HIV RNA levels were 34 (13-101) cells/mm3 and 5.4 (4.96-5.79) log copies/ml, respectively. At week 208, 84.6% of patients achieved HIV RNA loads <50 copies/ml, 88.5% continued NNRTI based regimens, 6.1% developed virologic resistance to NNRTIs, and 3.3% lost to follow up. Baseline CD4<50 cell/mm3 (p=0.019), and viral load ?50 copies/ml at 6 months post-ARV (p<0.001) were associated with treatment failure. At the end of the study, 39.8% lipoatrophy and 35.7% hyperlipidemia were identified. In conclusion, NNRTI-based regimens result in high virologic success; early undetectable viral load is key to predicting long-term virologic success.

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