Degradation in Pharmaceutical Creams: Ascorbic Acid Demonstrating Phenomenon: A Review
Safila Naveed* and Sidra Sajid
Jinnah University for Women, Karachi, Pakistan
- *Corresponding Author:
- Safila Naveed
Faculty of Pharmacy
Jinnah University for Women
E-mail: [email protected]
Received Date: November 25, 2015; Accepted Date: January 15, 2016; Published Date: January 22, 2016
Citation: Naveed S, Sajid S (2016) Degradation in Pharmaceutical Creams: Ascorbic Acid Demonstrating Phenomenon: A Review. J Bioequiv Availab 8:080-083. doi:10.4172/jbb.1000272
Copyright: © 2016 Naveed S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Pharmaceutical preparations for topical use are available in semi-solid dosage form termed as creams, have tendency to degrade it or there are some factors involve in the phenomenon. Aim: This review is compilation of studies performed on stability and degradation of Ascorbic acid (AA) creams by keeping goal in mind to finely demonstrate the central premise of this article that is to cover all aspects related to degradation in pharmaceutical creams. It was required to deep insight into degradation specifically in pharmaceutical creams, influences for phenomenon, degradation products, stability concerns and its effects on efficacy and safety of pharmaceutical creams.
Method: A literature survey was carried out using scientific websites for publications according to predetermined search sequence. Ascorbic acid cream was taken as model in few articles to illustrate relevant studies.
Result: Light, temperature, pH, microbial contamination, incompatibility of active ingredient or excipients, closure and packing material are the influential factors that may led pharmaceutical creams towards instabilities or degradation.
Conclusion: This article concludes with the overview of published articles that there are certain factors of degradation in creams and by routine stability testing and adopting appropriate precautionary measures degradation in creams can be controlled and minimize.