alexa Dendritic Cells in Drug-induced Toxicity | OMICS International | Abstract
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
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Review Article

Dendritic Cells in Drug-induced Toxicity

Raghu Tadagavadi1*, Girish Daginakatte2, Ganesan Ramesh3 and W Brian Reeves1

1Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA

2Department of Pharmacology, Aurigene Discovery Technologies Ltd., Bangalore 560100, India

3Department of Medicine and Vascular Biology Center, Georgia Regents University, Augusta, GA, USA

*Corresponding Author:
Raghu Tadagavadi
Department of Medicine/Nephrology
Pennsylvania State University College of Medicine
H040, 500 University Drive, Hershey, PA 17033, USA
Tel: 717-315-9175
E-mail: [email protected]

Received Date: December 24, 2013; Accepted Date: January 30, 2014; Published Date: February 06, 2014

Citation: Tadagavadi R, Daginakatte G, Ramesh G, Reeves WB (2014) Dendritic Cells in Drug-induced Toxicity. Clin Exp Pharmacol 4:150. doi: 10.4172/2161-1459.1000150

Copyright: © 2014 Tadagavadi R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Dendritic cells play a key role in immunity and tolerance. They are the most abundant population of leukocytes in a number of different tissues and organs. One of the important functions of dendritic cells is rapid recognition of pathogens or products of tissue injury. Depending on the nature of the inciting stimuli, they may elicit either pro- or antiinflammatory responses with or without the involvement of the adaptive immune system. Dendritic cells are generally considered beneficial to the host in microbial infections, but can be protective or detrimental in sterile inflammation. This unpredictable nature of dendritic cells is a reflection of the diverse and complex pathogenesis of sterile inflammatory responses. Drugs form a major group of stimuli for tissue injury and, in turn, a sterile inflammatory response. Although many studies have examined the role of dendritic cells in pathogenic infections, their function in drug related organ toxicity is very limited. Here, with a brief introduction of sterile inflammatory response, we review the reported findings about the dendritic cell role in drug induced toxicity.

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