alexa Dentin-Pulp Complex Regeneration Therapy Following Pulp Amputation
ISSN: 2379-1764

Advanced Techniques in Biology & Medicine
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Dentin-Pulp Complex Regeneration Therapy Following Pulp Amputation

Takahiko Morotomi1*, Yasuhiko Tabata2 and Chiaki Kitamura1
1Division of Endodontics and Restorative Dentistry, Department of Oral Functions, Kyushu Dental University, Japan
2Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Japan
Corresponding Author : Takahiko Morotomi
Division of Endodontics and Restorative Dentistry
Department of Oral Functions, Kyushu Dental University, Japan
Tel: 81932853081
E-mail: [email protected]
Received: October 30, 2015; Accepted: November 23, 2015; Published: November 30, 2015
Citation: Morotomi T, Tabata Y, Kitamura C (2015) Dentin-Pulp Complex Regeneration Therapy Following Pulp Amputation. Adv Tech Biol Med 3:153. doi:10.4172/2379-1764.1000153
Copyright: © 2015 Morotomi T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

It is generally accepted that dental pulp plays important roles in maintaining tooth. Pulp inflammation caused by dental caries or tooth fracture sometimes results in a severe pain, and pulpectomy to remove entire dental pulp is often performed by dentists to release a patient from the pain. After pulpectomy, the tooth without vital pulp loses its defensive ability and becomes vulnerable to exogenous stimuli. It will be valuable to establish a local regeneration therapy of dentin-pulp complex from residual dental pulp before pulpectomy to preserve abilities of dental pulp. We are trying to develop a novel therapy to induce regeneration of dentin-pulp complex following pulp amputation. In this approach, growth factors and a scaffold are exogenously supplied, while cells and blood vessels are induced from the residual dental pulp in the tooth root canal. Establishment of a newly method for pulp amputation without leading necrosis of the residual root pulp is also essential for the local regeneration therapy of dentin-pulp complex. In this mini review, we show our research strategy for local regeneration therapy of dentin-pulp complex.

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