Depletion of Glutathione during Oxidative Stress and Efficacy of N-Acetyl Cysteine: An Old Drug with New Approaches
Manjula Ramen T*
Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Chennai, India
- *Corresponding Author:
- Manjula Ramen T
Sri Ramachandra Medical College and Research Institute
Sri Ramachandra University, Chennai, India
E-mail: [email protected]
Received date: December 22, 2014; Accepted date: January 23, 2015; Published date: January 26, 2015
Citation: Manjula Ramen T (2015) Depletion of Glutathione during Oxidative Stress and Efficacy of N-Acetyl Cysteine: An Old Drug with New Approaches. Med chem 5:037-039. doi:10.4172/2161-0444.1000240
Copyright: © 2015 Manjula Ramen T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Glutathione, a non-protein thiol is most abundant in cells and glutathione-glutathione disulfide is the major redox pair in animal cells. Its synthesis is from two main enzymes gamma glutamyl cysteinyl synthetase and GSH synthetase. Also cysteine availability as N-acetyl cysteine and GSH feedback mechanism determines the reduced glutathione status of the cell. Additionally parenteral NAC, cystine, methionineare effective precursors of cysteine for tissue GSH synthesis. Adequate protein in the diet is crucial for tissue GSH synthesis. The role of NAC as an antioxidant, in gene expression, and regulation of cellular events must be emphasized. GSH deficiency contributes to oxidative stress and it progresses in diseased conditions such as HIV, AIDS, cancer, diabetes, also metabolic syndrome. New knowledge of the nutritional regulation of GSH metabolites is critical to improve health and treat these diseases.