alexa Dermoscopic-pathologic Correlation of Bowen Disease: A
ISSN: 2472-128X

Journal of Clinical & Medical Genomics
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Research Article

Dermoscopic-pathologic Correlation of Bowen Disease: A Case Series and Review of the Literatures

Sahra Emamzadehfard1-4, Hayadeh Ghaninejad1, Kambiz Kamyab-Hesari3,4, Homayoun Moslehi1 and Alireza Ghannadan1,3,4*
1Department of Dermatology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Department of Radiology, University of Pennsylvania, Philadelphia, USA
3Department of Dermatopathology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran
4Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author : Alireza Ghannadan, MD
Department of Dermatopathology, Razi Dermatology hospital
Vahdat-Eslami Street, Tehran, Iran
Tel: +982155159988
Fax: +982155155050
E-mail: [email protected]
Received: March 01, 2016 Accepted: March 16, 2016 Published: March 26, 2016
Citation: Emamzadehfard S, Ghaninejad H, Kamyab-Hesari K, Moslehi H, Ghannadan A (2016) Dermoscopic-pathologic Correlation of Bowen Disease: A Case Series and Review of the Literatures. J Clin Med Genomics 4:138. doi:10.4172/2472-128X.1000138
Copyright: © 2016 Emamzadehfard S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Introduction: We report the dermoscopic and pathologic features of the four patients with Bowen disease, an insitu squamous cell carcinoma, to assess the correlation of the pathologic-dermoscopic features of the Bowen disease. Materials and Methods: Dermoscopic images of all cases including nine lesions of the four patients were obtained by means of microderm. The images were analyzed by two experienced observer for searching global and local dermoscopic features. Four of nine lesions were excised and submitted for histopathologic examination. Results: The most frequently occurring dermoscopic features were found to be: glumerolar vessels (88.8%), gray to brown pigmentation (77.7%), scaling (55.5%), homogenous pigmentation (55.5%) and pigmented steak (22.2%). The histopathological evaluation of all cases revealed the dysmaturation of the keratinocytes, keratinocytic atypia and irregular psoriasiform acanthosis. In dermoscopic-histopathologic correlation, all lesions showed glomerular vessels in dermoscopy except one of the lesions. Conclusion: Dermoscopy may be considered as a helpful diagnostic test for the bowen disease to rule out other differential diagnosis. The microscopic slide may not be completely representative of the dermoscopic features, therefore, serial sections could be ordered. Further study is needed to assess the specificity and sensitivity of the dermoscopic criteria in differentiating BD from other pigmented and nonpigmented skin tumors as well as from inflammatory skin disorders.

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