alexa Desensitization to Allopurinol in Localized and Systemic Hypersensitivity Reactions | OMICS International | Abstract
ISSN: 2155-6121

Journal of Allergy & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

Desensitization to Allopurinol in Localized and Systemic Hypersensitivity Reactions

Gomes R, Ribeiro F, Faria E, Loureiro C* and Segorbe-Luís A

Immunoallergology Department, Coimbra University Hospital, Portugal

*Corresponding Author:
Loureiro Carlos
Immunoallergology Department
Coimbra University Hospital, Portugal
E-mail: [email protected]

Received date: May 15, 2013; Accepted date: June 14, 2013; Published date: June 20, 2013

Citation: Gomes R, Ribeiro F, Faria E, Loureiro C, Segorbe-Luís A (2013) Desensitization to Allopurinol in Localized and Systemic Hypersensitivity Reactions. J Allergy Ther 4:138. doi: 10.4172/2155-6121.1000138

Copyright: © 2013 Gomes R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: Allopurinol is, by far, the most frequently prescribed drug for the treatment of hyperuricemia, and the lack of alternatives makes, in case of a reaction, a desensitization procedure to be considered. With this survey, we aimed to do a characterization of patients with hypersensitivity (HS) reactions to allopurinol, who endured desensitization procedures.

Material and methods: Retrospectively, we analyzed the medical files of a group of patients that fit into our objective and were observed in our Department of Immunoallergology of Coimbra University Hospital, between 2007/2012. Demographic data, pathology underlying all prescriptions and concomitant diseases/regular medication, the desensitization protocol and all adverse reactions were taken into consideration.

Results: Six out of seven patients were male, aged from 37 to 79 (mean age of 64 ± 14 years) when undergoing the procedure. As far as the kind of reaction was concerned, three of the patients presented a fixed erythema, two urticaria with/without angiodema, one anaphylaxis and another one maculopapular rash at the time of desensitization. Five of them had gouty joint pathology, one hyperuricemia with chronic renal failure and another had both. Six among all of them presented associated cardiovascular pathology and were polymedicated. \\\\\\\\\\\\\\\\

The desensitization protocol used was adapted from Umpiérrez, with an initial dose of 10 μg up to 300 mg/day, adjusted in case of adverse reaction. There were no complications in three patients and the remaining had mild/ moderate skin reactions. In four patients with HS reaction during desensitization, only three needed to decrease the dose. The maintenance dose was achieved by extending the length of desensitization, between sixteen to twentytwo days.

Conclusion: In this series, the majority of patients had HS reactions during desensitization protocol and dose adjustment was necessary. However, we managed to achieve a maintenance dose in all of them.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7