Design and Characterization of Mucoadhesive Microspheres for Gastro- Retentive Delivery of Famotidine Hydrochloride
Shanthi Priya CH*
Department of Pharmaceutical Sciences, Srikrupa Institute of Pharmaceutical Sciences, Osmania University, Hyderabad, Telangana, India
- *Corresponding Author:
- Shanthi Priya CH
Department of Pharmaceutical Sciences
Srikrupa Institute of Pharmaceutical Sciences
Osmania University, Hyderabad, Telangana, India
E-mail: [email protected]
Received Date: April 21, 2015; Accepted Date: April 30, 2015; Published Date: May 07, 2015
Citation: Shanthi Priya CH (2015) Design and Characterization of Mucoadhesive Microspheres for Gastro-Retentive Delivery of Famotidine Hydrochloride. J Bioengineer & Biomedical Sci 5: 153. doi:10.4172/2155-9538.1000153
Copyright: © 2015 Shanthi Priya CH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This article illustrates the Design and Characterization of Mucoadhesive microspheres with Famotidine Hydrochloride as drug for Gastro-Retention of drug release. The microspheres were prepared by the Ion Gelation method and Thermal Cross Linking Method. In Ion Gelation method sodium alginate is used as a release controlling biopolymer and Calcium chloride is acts as hygroscopic cross linking agent. In Thermal Cross Linking Method egg albumin is used as binding agent and a Thermal energy is used as cross linking property. The characteristics like shape and structure of prepared microspheres by Optical microscopy and scanning electron microscopy, respectively. In vitro drug release studies were done and drug release was evaluated. Effect on the Mucoadhesion, drug Entrapment Efficiency of microspheres and Drug release were observed. The prepared microspheres exhibited prolonged drug release (17 hrs) the mean particle size increased as the concentration of sodium alginate increased, as the egg albumin concentration increases the Mucoadhesion increased and the drug release rate decreased at higher concentration of sodium alginate. Significant effect of the Encapsulation Efficiency of microspheres was observed. In vitro studies demonstrated the Gastro retentive delivery of drug from the microspheres.