Design and Evaluation of Wubei Gastr- Effervescent Tablet
College of Pharmacy, Liaoning University, 66 Chongshan Road, Shenyang 110036, China
- *Corresponding Author:
- Yan R
College of Pharmacy, Liaoning University
66 Chongshan Road, Shenyang 110036
Tel: 86 15671040801
E-mail: [email protected]
Received Date: November 25, 2014; Accepted Date: December 03, 2014; Published Date: December 10, 2014
Citation: Yan R (2015) Design and Evaluation of Wubei Gastr-Effervescent Tablet. J Bioequiv Availab 7:030-033. doi: 10.4172/jbb.1000210
Copyright: © 2015 Yan R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: A new solid preparation with instant effects like powder preparation was developed.
Introduction: Its instant dispersion results from a small amount of alkaline ingredients which would react with gastric acid in stomach to produce gas causing instant disintegration.
Methodology: According to relative specification in Chinese Pharmacopoeia, prescription was optimized.The tablet and the powders were administered to beagle dogs for the double cycle cross experiment. The plasma of the dogs was measured by LC-MS/MS and was compared with each other.
Result: The in vivo studies demonstrated that the Wubeigastr-effervescent tablet showed bio-equiavailability with traditional Wubei powder. This formulation could be applied to some liquid preparations without reducing their fastness of effects.