Design and Synthesis of Thiadiazole Derivatives as Antidiabetic Agents
Prasanna A Datar* and Tejashree A Deokule
Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune, India
- *Corresponding Author:
- Prasanna A Datar
Department of Pharmaceutical Chemistry
Sinhgad Institute of Pharmacy
Narhe, Pune, India
Tel: +91 9823161187
E-mail: [email protected]
Received date: March 26, 2014; Accepted date: April 26, 2014; Published date: April 28, 2014
Citation: Datar PA, Deokule TA (2014) Design and Synthesis of Thiadiazole Derivatives as Antidiabetic Agents. Med chem 4:390-399. doi:10.4172/2161-0444.1000170
Copyright: © 2014 Datar PA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Thiadiazole compounds have versatile activities such as anti-microbial, anti-inflammatory, anticancer, etc. Present study involves design of thiadiazole compounds as antidiabetic agent using docking studies. The designed molecules were synthesized and subjected to antidiabetic activity by in vitro and in vivo method. Compound TD7 was found to show potent antidiabetic activity in alloxan induced diabetes rat model. Molecular docking revealed that synthesized derivatives and target proteins were actively involved in binding and had significant correlation with biological activity.