alexa Design, Microwave-Assisted Synthesis and Biological Activities of 1,2,4-Triazol-3-Yl-Thiazolidin-4-Ones
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Design, Microwave-Assisted Synthesis and Biological Activities of 1,2,4-Triazol-3-Yl-Thiazolidin-4-Ones

Monia Aouali1*, Fatma Masmoudi3, Fatma Allouche1, Laurent El Kaim2, Fakher Chabchoub1 and Mohamed Trigui3

1Laboratoire de Chimie Appliquée: Hétérocycles, Corps Gras et Polymères, Faculté des Sciences, University of Sfax, Tunisie

2Laboratoire Chimie et Procédés, DCSO, UMR 7652, Ecole Nationale Supérieure de Techniques Avancées, 828 Bd des Maréchaux, France

3Laboratoire des Biopesticides, Centre de biotechnologie de Sfax Université de Sfax, Tunisie

Corresponding Author:
Monia Aouali
Laboratoire de Chimie Appliquée: Hétérocycles
Corps Gras et Polymères, Faculté des Sciences
University of Sfax, 3018 Sfax, Tunisie
Tel: +21626299719
E-mail: [email protected]

Received date: April 11, 2016; Accepted date: April 21, 2016; Published date: April 26, 2016

Citation: Aouali M, Masmoudi F, Allouche F, Kaim LE, Chabchoub F, et al. (2016) Design, Microwave-Assisted Synthesis and Biological Activities of 1,2,4-Triazol-3-Yl-Thiazolidin-4-Ones. Med chem (Los Angeles) 6:264-269. doi:10.4172/2161-0444.1000356

Copyright: © 2016 Aouali M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

A new 3-(5-alkyl-2-phenyl-2H-1,2,4-triazol-3-yl)thiazolidin-4-ones derivatives were obtained by condensation of 5-amino-1,2,4-triazoles, mercaptoacetic acid with aromatic aldehydes and catalyzed by Sm(SO3CF3)3 using microwave irradiation. The prepared compounds were tested for their antioxidant, antibacterial and antifungal proprieties. Some of these compounds displayed significant activities. Among them, compound 2e exhibited remarkable activity against a broad spectrum of Gram positive, negative bacteria and pathogenic fungal strains with low MIC values. The investigation of the mode of action of the most potent antifungal compounds on the fungus Pythium phanidermatum showed a membrane alteration and distortions of hyphal morphology. The newly synthesized compounds exhibited also promising radical scavenging activity.

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