alexa Design of Size-Tunable Molecularly Imprinted Polymer fo
ISSN: 2155-6210

Journal of Biosensors & Bioelectronics
Open Access

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Research Article

Design of Size-Tunable Molecularly Imprinted Polymer for Selective Adsorption of Pharmaceuticals and Biomolecules

Shih-Hui Lee1,2 and Ruey-An Doong2,3*

1Department of Chemistry, University of California, Irvine, CA, USA

2Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101, Sec. 2, Kuang Fu Road, Hsinchu, 30013, Taiwan

3Institute of Environmental Engineering, National Chiao Tung University, 1001, University Road, 30010, Hsinchu, Taiwan

*Corresponding Author:

Ruey-an Doong
Institute of Environmental Engineering
National Chiao Tung University
1001 University Road
Hsinchu, 30010, Taiwan
Tel: +886-3-5712121
Fax: +886-35725958
E-mail: [email protected]

Received Date: November 30, 2016 Accepted Date: December 07, 2016 Published Date: December 17, 2016

Citation: Lee SH, Doong RA (2016) Design of Size-Tunable Molecularly Imprinted Polymer for Selective Adsorption of Pharmaceuticals and Biomolecules. J Biosens Bioelectron 7: 228. doi: 10.4172/2155-6210.1000228

Copyright: © 2016 Lee SH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The tunable and nano-sized materials have recently been received much attention due to the unique physical and chemical properties which are different from bulk materials. Moleculary imprinted polymer (MIP) nanoparticles with special functions provide opportunities for transformative approaches for a wide of variety applications such as imaging, adsorbent, therapeutic reagents, drug delivery vehicles, sensors, toxin neutralization and enzyme inhibition. In this review, the principle, fabrication approaches, parameters to affect affinity and selectivity of MIP were summarized. The application of MIPs for removal of pollutants as well as the separation of macrobiomolecules was also introduced. Through the tuning processes, MIPs can satisfy the needs of simple, fast, cost-effective and robust. In addition, MIPs are easily to be integrated with the diagnosis and separation system, which have instinct advantages in separation, drug delivery, therapeutic and diagnosis fields. Contents shown in this review clearly show that MIPs are highly potential materials for facile design for not only separating the molecules from small molecules to biomolecules by precipitation polymerization but can also be used for imaging, cell tissue engineering and antidotes.

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