alexa Design, Synthesis and Anticancer Screening of Novel Pyrazole Derivatives Linking to Benzimidazole, Benzoxazole and Benzothiazole | OMICS International
ISSN: 2161-0444

Medicinal Chemistry
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Special Issue Article

Design, Synthesis and Anticancer Screening of Novel Pyrazole Derivatives Linking to Benzimidazole, Benzoxazole and Benzothiazole

Mohamed A Abdelgawad1, Khaled RA Abdellatif1* and Osama M Ahmed2,3

1Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

2Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt

3Faculty of Oral and Dental Medicine, Nahda University, New Beni-Suef City, Beni-Suef, Egypt

*Corresponding Author:
Khaled RA Abdellatif
Organic Chemistry Department
Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt
Tel: 00201002535444
Fax: 0020822317958
E-mail: [email protected]

Received date: February 11, 2014; Accepted date: February 26, 2014; Published date: February 28, 2014

Citation: Abdelgawad MA, Abdellatif KRA, Ahmed OM(2014) Design, Synthesis and Anticancer Screening of Novel Pyrazole Derivatives Linking to Benzimidazole, Benzoxazole and Benzothiazole. Med chem S1:001. doi:10.4172/2161-0444.S1-001

Copyright: © 2014 Abdelgawad MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Substituted aromatic amines were diazotized followed by coupling with malononitrile to afford substituted phenyl hydrazono-malononitrile compounds 2a-c. Compounds 3a-c were prepared through the reaction of substituted phenyl hydrazono-malononitriles 2a-c with phenyl hydrazine, while the reaction of compounds 2a-c with hydrazine hydrate afforded diamino compounds 4a-c. The diamino compounds 4a-c was condensed with different substituted aromatic aldehydes to yield N-benzylidine pyrazole diamines 5a-i. The structure of the newly synthesized compounds was confirmed by IR, 1H NMR, MS spectral data and elemental analysis. Twelve novel compounds 3a-c and 5a-i were screened for their anticancer activities against breast carcinoma (T47D) and human hepatocarcinoma cell lines (Huh- 7) compared with Doxorubicin. The detailed synthesis, spectroscopic data and anticancer activities of the synthesized compounds were reported.

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