alexa Design, Synthesis and Biological Evaluation of Novel 1,
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Design, Synthesis and Biological Evaluation of Novel 1, 2, 5-Substituted Benzimidazole Derivatives as Gastroprotective Anti-inflammatory and Analgesic Agents

Monika Gaba1* and Chander Mohan2

1Department of Pharmaceutical Sciences, ASBASJSM College of Pharmacy, Bela, Ropar, Punjab, India

2Rayat-Bahra Institute of Pharmacy, Hoshiarpur, Punjab, India

*Corresponding Author:
Monika Gaba
Pharmaceutical Chemistry
ASBASJS Memorial College of Pharmacy
Bela-140 111 (Ropar) India
Tel: +919872390321
E-mail: [email protected], [email protected]

Received date: January 12, 2015; Accepted date: February 06, 2015; Published date: February 09, 2015

Citation: Gaba M, Mohan C (2015) Design, Synthesis and Biological Evaluation of Novel 1, 2, 5-Substituted Benzimidazole Derivatives as Gastroprotective Anti-inflammatory and Analgesic Agents. Med chem 5:058-063. doi:10.4172/2161-0444.1000243

Copyright: © 2015 Gaba M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

In the present investigation, in order to identify GI-safe anti-inflammatoryand analgesic agents, a series of novel 1, 2 and 5-substituted benzimidazole derivatives were synthesized and biologically evaluated. The results demonstrated that the compounds 3b, 4b, and 5b could serve as gastroprotective lead compounds for developing a novel class of potent as well as orally active anti-inflammatory and analgesic agents in the future research.

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