alexa Design, Synthesis and Biological Evaluation of Novel Class Diindolyl Methanes (DIMs) Derived from Naturally Occurring Phenolic Monoterpenoids
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Design, Synthesis and Biological Evaluation of Novel Class Diindolyl Methanes (DIMs) Derived from Naturally Occurring Phenolic Monoterpenoids

Jamatsing D Rajput, Suresh D Bagul, Samina K Tadavi, Pravin S Karandikar and Ratnamala S Bendre*

School of Chemical Sciences, North Maharashtra University, Jalgaon, Maharashtra, India

*Corresponding Author:
Prof. (Mrs.) Ratnamala S. Bendre
Head, Department of Pesticides and Agrochemical
School of Chemical Sciences, North Maharashtra
University, Jalgaon-425 001, Maharashtra, India

Received date: February 03, 2016; Accepted date: February 19, 2016; Published date: February 23, 2016

Citation: Rajput JD, Bagul SD, Tadavi SK, Karandikar PS, Bendre RS (2016) Design, Synthesis and Biological Evaluation of Novel Class Diindolyl Methanes (DIMs) Derived from Naturally Occurring Phenolic Monoterpenoids. Med chem (Los Angeles) 6:123-128. doi:10.4172/2161-0444.1000336

Copyright: © 2016 Rajput JD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Several Diindolyl alkanes and their derivatives have been isolated from plant and marine sources. Among the various derivatives of indoles, Diindolyl methanes have wide medicinal applications such as to induce apoptosis in human cancer cells, antibacterial, Anti-inflammatory, antiviral and hormonal control activities. Therefore, they play essential role in marine as well as terrestrial living systems. In present studies we report novel class of Diindolyl methanes prepared from natural phenolic monoterpenoids, via ortho formylation of phenolic monoterpenoids (Carvacrol, Thymol and Eugenol), followed by synthesis, characterization, anticancer, antioxidant and α-amylase inhibitory activities. All the synthesized derivatives show moderate anticancer activities against human breast cell line MCF7, good antioxidant and α-amylase inhibitory activities using DPPH and α-amylase assay respectively.


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