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ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Design, Synthesis, and Evaluation of Glycopeptides Containing Glucosamine

Guichao Xu1, Xiaomin Wang2, Meng Zhang1, Li Zeng1, Hong Li1, Pengchao Gao1 and Jianwei Zhang1*

1College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PRC, China

2Department of Physiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing 100069, PRC, China

*Corresponding Author:
Jianwei Zhang
College of Pharmaceutical Sciences
Capital Medical University
Beijing 100069, PRC, China
Tel: 86-10-8391-1522
Fax: 86-10-8391-1533
E-mail: [email protected]

Received date: May 21, 2014; Accepted date: June 27, 2014; Published date: June 29, 2014

Citation: Xu G, Wang X, Zhang M, Zeng L, Li H, et al. (2014) Design, Synthesis, and Evaluation of Glycopeptides Containing Glucosamine. Med chem 4:494-500. doi: 10.4172/2161-0444.1000184

Copyright: © 2014 Xu G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In this study, several novel peptidomimetics were designed and synthesized as potential anti-inflammatory agents. Their anti-inflammatory activity was evaluated using a xylene-induced ear edema model assay. Some of the compounds demonstrated inhibitory activity against xylene-induced inflammation similar to the positive control, aspirin.

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