Design, Synthesis, and Evaluation of Glycopeptides Containing Glucosamine
- *Corresponding Author:
- Jianwei Zhang
College of Pharmaceutical Sciences
Capital Medical University
Beijing 100069, PRC, China
E-mail: [email protected]
Received date: May 21, 2014; Accepted date: June 27, 2014; Published date: June 29, 2014
Citation: Xu G, Wang X, Zhang M, Zeng L, Li H, et al. (2014) Design, Synthesis, and Evaluation of Glycopeptides Containing Glucosamine. Med chem 4:494-500. doi: 10.4172/2161-0444.1000184
Copyright: © 2014 Xu G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In this study, several novel peptidomimetics were designed and synthesized as potential anti-inflammatory agents. Their anti-inflammatory activity was evaluated using a xylene-induced ear edema model assay. Some of the compounds demonstrated inhibitory activity against xylene-induced inflammation similar to the positive control, aspirin.