Design-Syntheses, Characterization and Biological Activity Studies of Azobenzen-P,PÃªÂÂ-Di(3,1-Benzoxazin-4-One-2yl) and Azobenzen-P,PÃªÂÂ-Di[(3- Substituted 3(4H)Quinazolinone-2yl] Derivatives
- *Corresponding Author:
- Zainab A Jabarah
Basic Science Division, College of Agriculture
University of Baghdad, Baghdad, Iraq
E-mail: [email protected]
Received Date: May 22, 2017; Accepted Date: May 24, 2017; Published Date: June 12, 2017
Citation: Aiube ZH, Jabarah ZA (2017) Design-Syntheses, Characterization and Biological Activity Studies of Azobenzen-P,Pê-Di(3,1-Benzoxazin-4-One-2yl) and Azobenzen-P,Pê-Di[(3- Substituted-4(3h)Quinazolinone-2yl] Derivatives. Chem Sci J 8:156. doi: 10.4172/2150-3494.1000156
Copyright: © 2017 Aiube ZH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sixteen azobenzene-p,pÃªÂÂ-di[3-substituted-4(3H)quinazolinone-2yl] were synthesized from reaction of azobenzenp, pÃªÂÂ-di(3,1-benzoaxzin-4-one-2yl) with amino-moieties nucleophlies, like hydrazinehydrate, hydroxylamine, p,toluidine, p-aminobenzene sulphonamide, 2-pyrimidine, 5-nitro-2-aminopyridine, ethyleneamine,5-(p-bromo) phenyl-2-aminothiazol, p,pÃªÂÂ-diamino diphenyl sulphone, quinidine hydrochloride, urea, thiourea, 3,5-dimethyl- 2-phenyl-4-aminopyrazolin-3-one, N(5-methyl-3-isoxazolyl)-p-aminobenzen sulphonamide, semicarbazide and thiosemicarbazide, in a molar ratio (1:2) respectively. azobenzen-p,pÃªÂÂ-di(3,1-benzoaxzin-4-one-2yl), was synthesized by following serial synthetic pathway. Reductive-condensation of p-nitrobenzoic acid in basic media give azobenzenp, pÃªÂÂ-dicarboxylic acid, then treated with thionyl chloride to give azobenzen-p,pÃªÂÂ-diacid chloride. It condensed with anthranilic acid to give azobenzen-p,pÃªÂÂ-[(dibenzoic acid-2yl)dicarboxamide], upon treatment with thionyl chloride give azobenzen-p,pÃªÂÂ-di(3,1-benzoaxzin-4-one-2yl). All synthesized compounds characterized by FTIR, 1HNMR, 13CNMR and mass spectral analyses. All synthesized azobenzen-p,pÃªÂÂ-di(3,1-benzoaxzin-4-one-2yl), and sixteen azobenzenep, pÃªÂÂ-di[3-substituted-4(3H)quinazolinone-2yl] compounds, were examined as antibacterial agents against gm(+ve and –ve) bacteria, and antifungal agents. Results showed abroad extended to moderate effects as antibacterial and antifungal agents.