Detecting Psychiatric Profile in Genetic Syndromes: A Comparison of Down Syndrome and Williams SyndromeStefano Vicari1*, Floriana Costanzo1, Marco Armando1, Giovanni Carbonara1, Pamela Varvara1, Cristina Caciolo1, Chiara Gagliardi2, Tiziana Gianesini3, Paolo Alfieri1, Rossella Capolino1 and Deny Menghini1
- *Corresponding Author:
- Stefano Vicari, MD
Bambino Gesù Children’s Hospital
Piazza S. Onofrio 4, I-00165, Roma
E-mail: [email protected]
Received date: September 30, 2015; Accepted date:December 16, 2015; Published date: January 03, 2016
Citation: Vicari S, Costanzo F, Armando M, Carbonara G, Varvara P, et al. (2016) Detecting Psychiatric Profile in Genetic Syndromes: A Comparison of Down Syndrome and Williams Syndrome. J Genet Syndr Gene Ther 7:279. doi:10.4172/2157-7412.1000279
Copyright: © 2016 Vicari S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The occurrence and co-occurrence of psychiatric disorders have been more frequently reported in people with Intellectual Disability(ID) than in the general population. The present study was aimed at verifying whether the psychiatric profile of individuals with ID is just a consequence of ID or derives from a specific genotype. The psychiatric profile of 112 individuals with Down syndrome (DS) and 85 with Williams syndrome (WS) was examined. The interactions between psychiatric symptom clusters and the effect of age were also investigated. Participants with WS had higher rates of psychiatric disorders, and, specifically, of Anxiety disorders and Psychosis than DS. However, the psychiatric profile changed by age, since Anxiety disorder was higher in individuals with WS compared to DS in young age, while Psychosis in old age. A relation between the occurrence of disorders, as Anxiety disorder and Mood Disorder, was found only in participants with WS. Moreover, distinct Anxiety and Behavior Disorder subtypes emerged between groups. Results indicate that the genetic etiology of ID differently affects the psychiatric characteristics of the groups and suggest the importance of a targeted psychiatric care for individuals with WS and DS.