alexa Detection and Analysis of Regional Trends of Klebsiella pneumonia Causing Liver Abscess
ISSN: 2327-5073

Clinical Microbiology: Open Access
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Research Article

Detection and Analysis of Regional Trends of Klebsiella pneumonia Causing Liver Abscess

Yunfang Sun1,2, Hua Wu1,3 and Dingxia Shen1*

1Department of Microbiology, Chinese General Hospital of People’s Liberation Army, Beijing 100853, China

2Department of Microbiology, Shandong Medical College, Linyi, 276000, China

3Department of Microbiology, Hainan Provincial People's Hospital, Haikou, 570311, China

*Corresponding Author:
Dingxia Shen
Department of Microbiology
Chinese General, Hospital of People’s
Liberation Army, Beijing 100853, China
Tel: +15866930039
E-mail: [email protected]

Received date: May 13, 2015 Accepted date: July 13, 2015 Published date: July 20, 2015

Citation: Sun Y, Wu H, Shen D (2015) Detection and Analysis of Regional Trends of Klebsiella pneumonia Causing Liver Abscess. Clin Microbiol 4:208. doi:10.4172/2327-5073.1000208

Copyright: © 2015 Sun Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Hypervirulent variant of Klebsiella pneumoniae is the major pathogen causing liver abscess.
Methods: A retrospective study was conducted in 240 patients with cultures positive for K. pneumoniae hospitalized in the Chinese PLA General Hospital from May 2013 to August 2014. The clinical and molecular data of the hypervirulent K. pneumoniae (hvKP) causing liver abscess were analyzed.
Results: Among 240 strains of K. pneumoniae, hvKP accounted for 42.5% (102/240), hvKP causing liver abscess were 37 strains, accounting for 36.3% (37/102), patients with diabetes were 11 (11/37, 29.7%), 13 (13/37,35.1%) patients were diagnosed as fever of unknown origin at first, 7 (7/37,18.9%) patients with tumor, the rest 6 (6/37,16.2%) patients with postoperative infection or other site infection. Univariate analysis revealed the following risk factors for hvKP causing liver abscess: string test (odds ratio (OR), 11.306 [95% confidence interval (CI), 3.579-35.711]), serotype K1 (OR, 3.109 [95% CI, 1.338-7.222]) and fever of unknown origin (OR, 6.921 [95% CI, 2.503-19.136]). The results detected by multiplex PCR were consistent with single PCR. 102 strains of hvKP were tested the sensitivity to 14-19 drug, 37 strains caused liver abscess were not found with ESBL.
Conclusions: The detection of string test combined with rmpA and aerobactin can better identify hvKP. Patients with liver abscess generally were diabetes, but some patients didn’t have other disease. There is not much difference about the chance to be attacked by hvKP among male and female. ESBL was not detected among the hvKP causing liver abscess. Multiplex PCR assay could detect hvKP quickly.


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