alexa Detection of IgM against Dengue Virus in Clinically Suspected Patients Presenting at a Tertiary Care Centre, Narayani Zone, Nepal | OMICS International | Abstract
ISSN: 2329-891X

Journal of Tropical Diseases & Public Health
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Research Article

Detection of IgM against Dengue Virus in Clinically Suspected Patients Presenting at a Tertiary Care Centre, Narayani Zone, Nepal

Hari P Nepal1, Shamshul Ansari1, Narayan Gyawali2,3, Rajendra Gautam1, Rama Paudel4, Sony Shrestha1, Brihaspati Rimal5, Anju Acharya1, Moti L Chapagain1 and Andrew W Taylor-Robinson3*

1Department of Microbiology, Chitwan Medical College Teaching Hospital, Bharatpur, Nepal

2Department of Microbiology, Nepal Medical College, Kathmandu, Nepal

3School of Medical & Applied Sciences, Central Queensland University, Rockhampton, Australia

4Department of Pharmacology, College of Medical Sciences-Teaching Hospital, Chitwan, Nepal

5Department of Biochemistry, Chitwan Medical College Teaching Hospital, Bharatpur, Nepal

*Corresponding Author:
Andrew W Taylor-Robinson
School of Medical & Applied Sciences
Central Queensland University
Bruce Highway, Rockhampton
QLD 4702, Australia
Tel: 61749232008
E-mail: [email protected]

Received Date: April 08, 2014; Accepted Date: May 23, 2014; Published Date: May 26, 2014

Citation: Nepal HP, Ansari S, Gyawali N, Gautam R, Paudel R, et al. (2014) Detection of IgM against Dengue Virus in Clinically Suspected Patients Presenting at a TertiaryCare Centre, Narayani Zone, Nepal. J Trop Dis 2:139. doi: 10.4172/2329-891X.1000139

Copyright: © 2014 Nepal HP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: The global prevalence of dengue has increased dramatically in recent decades, with currently 50 million clinical cases and up to 5 million hospitalisations annually. Caused by one of five closely related but antigenically distinct virus serotypes (DEN-1 to DEN-5), dengue is an emerging mosquito-borne viral disease and an important public health problem in Nepal.

Objectives: This study was designed to determine the occurrence of dengue in clinically suspected patient in Narayani Zone, Central Nepal.

Methods: A descriptive cross-sectional study was conducted between January 2010 and December 2011 at Chitwan Medical College Teaching Hospital, Bharatpur, the fifth largest city of Nepal. A total of 590 blood samples were collected and processed for anti-dengue immunoglobulin (Ig)M by antibody isotype-capture enzyme-linked immunosorbent assay.

Results: Positive detection of anti-dengue IgM was found in 8.5% of patients (50/590 cases). The highest number of dengue cases was observed in the 21-30 years age group with greater predilection in males than in females. The positive cases showed higher frequency in winter season than at other times of year. There was a significantly greater prevalence of dengue among residents of urban locations compared to those from rural areas.

Conclusions: A high percentage of dengue positivity among suspected patients demands early investigation and careful management to prevent significant outbreaks of dengue fever and dengue haemorrhagic fever.


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