Martin Anderson, Gunnar Engström, Lars H Nordenmark, Dag Mohlkert, Elmira Rouzbeh, Maria Gerhardsson de Verdier, Ulf Nihlén, Thomas Fehniger, Magnus Dahlbäck and Magnus Svartengren
Purpose: Computed tomography (CT) has been applied to assess signs of early disease in a population study. Comparisons were made of histogram based methods to quantitatively determine lung density; relative area of emphysema below -910 and -950 Hounsfield units, and 15th percentile density (RA -910, RA -950 and PD15), as well as visual assessment of computed tomography (CT) images, to lung function indices in a population based study of smokers and non-smokers.
Methods: 138 subjects from a study of lung function in COPD were included in the study. Computerised assessments and visual scoring were used to analyse CT scans of different regions of identifying subjects with emphysema.
Results: Subjects visually diagnosed with centrilobular emphysema had significantly lower lung density (n=27, PD15=-932 HU, RA-950=6.6%) compared to subjects without emphysema (n=106, PD15=-917 HU, RA-950=2.3%). In the group with low PD15, the proportion with visually determined centrilobular emphysema was 38%, compared to 15% in the groups with high PD15.
Conclusion: Evaluation of patterns of lung attenuation by automated assessment and visual scoring provided similar classifications of disease in patients with mild COPD but differed in identifying regions of low density in healthy subjects. Visual assessment showed better correlation to both lung function and smoking habits than quantitative measures in this study. Quantitative measures should be used in the upper third of the lungs to detect smoking induced emphysema. Measurements of early attenuation changes within healthy subjects may require additional measures of validation by radiologists by visual assessment.
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