Determination of Carteolol in Pure and Pharmaceutical Formulation by Spectrophotometric Method
Malek Okdeh*, Chahid Moustpha and Mohammad Shraitah
Department of Chemistry, Faculty of Science, Teshreen University, Lattakia, Syria
- *Corresponding Author:
- Malek Okdeh
Department of Chemistry, Faculty of Science
E-mail: [email protected]
Received date: January 18, 2016; Accepted date: February 11, 2016; Published date: February 15, 2016
Citation: Okdeh M, Moustpha C, Shraitah M (2016) Determination of Carteolol in Pure and Pharmaceutical Formulation by Spectrophotometric Method. Med chem (Los Angeles) 6:115-118. doi:10.4172/2161-0444.1000334
Copyright: © 2016 Okdeh M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
An accurate, simple, fast, and good sensitive Spectrophotometric method have been developed for the determination of Carteolol based on the formation of complex (ion-pair complexes) between the Carteolol (CRT) and Alizarin yellow R Sodium salt (AR) at pH=11.20. This reaction produces a complex red color which is absorbed maximally at 500 nm. Beer’s law was obeyed in the range of 1.80-197.30 ug/mL with molar absorptivity of 1.7663×103 L mole-1cm-1. The effects of analytical parameters on the reported system were investigated. The results were validated statistically. The proposed method was applied to commercially available tablets. Interferences of the other ingredients and excipients were not observed.