alexa Determination of Clopidogrel Bisulphate in Plavix Table
ISSN: 2155-9821

Journal of Bioprocessing & Biotechniques
Open Access

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Research Article

Determination of Clopidogrel Bisulphate in Plavix Tablet and Human Biological Fluids Utilizing Chemically Modified Carbon Paste Sensor

Amal Fouad Khorshid*
Pharmaceutical Analytical Chemistry department, Faculty of Pharmacy, Nahda University, NUB, Egypt
Corresponding Author : Amal Fouad Khorshid
Pharmaceutical Analytical Chemistry Department
Faculty of Pharmacy, Nahda University, NUB, Egypt
Tel: 20128-0875558
E-mail: [email protected]
Received February 24, 2014; Accepted March 26, 2014; Published April 02, 2014
Citation: Khorshid AF (2014) Determination of Clopidogrel Bisulphate in Plavix Tablet and Human Biological Fluids Utilizing Chemically Modified Carbon Paste Sensor. J Bioprocess Biotech 4:154 doi: 10.4172/2155-9821.1000154
Copyright: © 2014 Khorshid AF. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

The fabrication and the performance response characteristics of a novel sensitive, selective, simple, and rapid sensor for the determination of Clopidogrel bisulphate (CLO-H2SO4) were described. The sensing modified carbon paste sensor comprised of an ion-pair based on Clopidogrel with silico tungastate (CLO-ST) where this study included: composition, usable pH range, response time and temperature. The sensorex hibiteda wide linear dynamic concentration ranging from 1.00x10−7-1.00x10−2 and the usable pH ranges from 1.2-4.8 with the response time ranging from (5-8 sec) which is much faster compared to liquid ISEs with a detection limit equals 0.34 nM. The selectivity of the sensor (CLOH2SO4) was applied with respect to a many of organic and inorganic cations, amino acids and sugars. The application of the sensor (CLO-H2SO4) for its determination was utilized in bulk powder, Plavix Tablet, human (serum-urine) and monitoring Plavix tablet dissolution rates using calibration curve, standard addition, and the potentiometric titration methods. The obtained results were statistically analyzed in both accuracy and precision and were compared using the US pharmacopeia method where there is no significant difference was observed.

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