alexa Determination of Hematological Effects of Methanolic Leaf Extract of S. incanum in Normal Mice
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Determination of Hematological Effects of Methanolic Leaf Extract of S. incanum in Normal Mice

Njagi J Muriithi*, Gitahi S Maina, Njagi M Mugendi, Mwangi B Maina, Mworia J Kiambi, Juma K Kelvin, Aliyu Umar, Mwonjoria K John, Njoroge W Ann, Abdirahman YA, Ngugi M Piero and Njagi NM Eliud

Department of Biochemistry and Biotechnology, Kenyatta University, P.O Box 43844-00100, Nairobi, Kenya

*Corresponding Author:
Njagi J Muriithi
Department of Biochemistry and Biotechnology
Kenyatta University, P.O Box 43844-00100
Nairobi, Kenya
Tel: +254 726 375 834
E-mail: [email protected]

Received date: September 22, 2015; Accepted date: October 13, 2015; Published date: October 16, 2015

Citation: Muriithi NJ, Maina GS, Mugendi NM, Maina MB, Kiambi MJ, et al.(2015) Determination of Hematological Effects of Methanolic Leaf Extract of S. incanum in Normal Mice. Pharm Anal Acta 6:429. doi: 10.4172/2153-2435.1000429

Copyright: © 2015 Muriithi NJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Medicinal plants and herbs have been used for ages for the purposes of enhancing and maintaining health and organic resistance against body infection. This is due to their ready availability and arguably efficacious state, therefore offering an alternative remedy in enhancing hematological parameters. Various chemical constituents of Solanum incanum (Linn) are believed to possess therapeutic effects on hematological parameters, but these effects have not been subjected to systematic scientific studies to substantiate and ascertain the therapeutic claims made regarding their clinical utility. This study investigates the hematological effects of S. incanum (Linn) in normal mice. The experimental mice groups were treated with methanolic seed extracts of S. incanum (Linn) at concentrations of 50 mg/kg and 100 mg/kg orally once per two days for a period of fourteen days. Hematological parameters and indices of unclotted blood were determined using standard protocols. Phytochemicals were determined using standard protocols. Seven and fourteen days after administration of methanolic seed extracts of S. incanum at the dose level of 50 mg/kgbw, there was significant increase in erythrocytes, hemoglobin and hematocrit counts while the dose level of 100 mg/kgbw caused significant increase in hematocrit count fourteen days after administration of the extract. There was a significant increase in levels of total white blood cells, neutrophils and basophil counts seven and fourteen days after administration of the methanolic seed extract of S. incanum at the dose level of 50 mg/kgbw. The dose level of 50 mg/kgbw of methanolic seed extract of S. incanum caused a significant increase in platelet, plateletcrit, MPV, and PDW profiles after seven days. In addition phytochemical screening results showed that the seed extract of S. incanum (Linn) had phytochemicals associated with erythropoietin promoting activity, immunostimulatory activities and thrombopoietin stimulation.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords