alexa Determination of Ti from TiO2 Nanoparticles in Biological Materials by Different ICP-MS Instruments: Method Validation and Applications | OMICS International | Abstract
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
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Research Article

Determination of Ti from TiO2 Nanoparticles in Biological Materials by Different ICP-MS Instruments: Method Validation and Applications

Yacine Nia1, Sandrine Millour1, Laurent Noël1, Petra Krystek2, Wim de Jong3 and Thierry Guérin1*

1Anses, Food Safety Laboratory–Maisons-Alfort, Chemical Food Contaminants Department, Metallic Trace Elements and Minerals Unit, Maisons-Alfort, France

2Philips Innovation Services (PInS), High Tech Campus 11, Eindhoven, The Netherlands

3National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

*Corresponding Author:
Thierry Guérin
Anses, Food Safety Laboratory–Maisons-Alfort
Chemical Food Contaminants Department
Metallic Trace Elements and Minerals Unit, 14
rue Pierre et Marie Curie, F-94706 Maisons-Alfort, France
Tel: 33-149-772-711
E-mail: [email protected]

Received Date: January 14, 2015; Accepted Date: February 09, 2015; Published Date: February 19, 2015

Citation: Nia Y, Millour S, Noël L, Krystek P, Jong W, et al. (2015) Determination of Ti from TiO2 Nanoparticles in Biological Materials by Different ICP-MS Instruments: Method Validation and Applications. J Nanomed Nanotechnol 6:269. doi: 10.4172/2157-7439.1000269

Copyright: © 2015 Nia Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The accurate determination of nanoparticles (NPs) content in biological samples is of great interest for studying its potential impacts on health. This paper describes a method validation process for Ti determination from TiO2 NPs in biological matrixes using a closed-vessel microwave digestion with a mixture of 3 mL of HNO3 and 0.4 mL of HF and a detection by quadrupole inductively coupled plasma-mass spectrometry (Q-ICP-MS), in both standard and collision/ reaction cell (CCT) modes. As no suitable certified reference materials are available, several internal reference materials (IRMs) were prepared precisely and they were used for the optimisation and the analytical quality assurance of the method. Several criteria such as linearity, limits of quantification (LOQ), precision under repeatability conditions and intermediate precision reproducibility were evaluated. Furthermore, the method was compared on different Q-ICP-MS devices and on a high resolution (HR)-ICP-MS using the prepared IRMs and various samples of rat tissues exposed to two different sizes of TiO2 NPs. The results demonstrated that the Q-ICP-MS method evaluated permitted an accurate determination of Ti present as TiO2 NPs in both standard and CCT modes, with a greater accuracy in CCT mode at low concentration levels near the LOQ of 0.10 mg kg-1.


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