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Determination of Trace Metals in Human Seminal Plasma Using Inductively Coupled Plasma Mass Spectrometry and Multivariate Statistical Analyses for Sperm Parameters | Abstract

Journal of Molecular Biomarkers & Diagnosis
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Research Article

Determination of Trace Metals in Human Seminal Plasma Using Inductively Coupled Plasma Mass Spectrometry and Multivariate Statistical Analyses for Sperm Parameters

Masatoki Katayama1*, Satoru Kaneko2, Kiyoshi Takamatsu2, Takahiro Tsukimura1 and Tadayasu Togawa1

1Department of Functional Bioanalysis, Meiji Pharmaceutical University, 2?522?1, Noshio, Kiyose, Tokyo 204?8588, Japan

2Reproduction Center (Gynecology), Ichikawa General Hospital, Tokyo Dental College, Ichikawa, Chiba 272?0824, Japan

*Corresponding Author:
Masatoki Katayama
Department of Functional Bioanalysis
Meiji Pharmaceutical University, 2?522?1
Noshio, Kiyose, Tokyo 204?8588, Japan
E-mail: [email protected]

Received date: July 26, 2013; Accepted date: August 28, 2013; Published date: August 30, 2013

Citation: Katayama M, Kaneko S, Takamatsu K, Tsukimura T, Togawa T (2013) Determination of Trace Metals in Human Seminal Plasma Using Inductively Coupled Plasma Mass Spectrometry and Multivariate Statistical Analyses for Sperm Parameters. J Mol Biomark Diagn 4:147. doi:10.4172/2155-9929.1000147

Copyright: © 2013 Katayama M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


We have simultaneously determined the presence of 30 different trace metals in human seminal plasma by Inductively Coupled Plasma Mass Spectrometry (ICP−MS). To date, high concentrations of metals (e.g. Zn, Cu, Mg and Fe) in seminal plasma have been sporadically reported and only few reports have discussed the relationships between trace metals and human semen profiles. Ninety-four seminal plasma specimens were first classified in three groups (normozoospermia, oligozoospermia, and azoospermia) according to the WHO guideline for sperm concentration. No significant differences were found among the three groups for all the metals examined. The concentration of metals in the specimens were then compared with sperm concentration, motility, morphology, and volume using multivariate regression analysis, principal component analysis (PCA) and cluster analysis. The most cumulative contribution ratio and grouping were extracted for profile analysis. Zn showed a positive correlation with motility and morphology (r = 0.3142 and 0.6205), whereas trace metals such as Se and Tl showed positive correlations with all sperm properties. Heavy metals such as Cu, Cd, and Cr also showed high positive or negative correlations with sperm properties. In summary, this study is the first to report the simultaneous determination of metals (in addition to the commonly reported Zn), including trace and heavy metals, in human seminal plasma as analyzed by multivariate regression analysis


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