alexa Development and Applications of Microfluidic Devices for Cell Culture in Cell Biology
ISSN: 2168-9547

Molecular Biology: Open Access
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Review Article

Development and Applications of Microfluidic Devices for Cell Culture in Cell Biology

Linglu Yi1,2 and Jin-Ming Lin2*

1School of Science, Beijing University of Chemical Technology, Beijing 100029, PR China

2Department of Chemistry, Beijing Key Laboratory of Micronalytical Methods and Instrumentation, Tsinghua University, Beijing 100084, PR China

*Corresponding Author:
Dr. Jin-Ming Lin
Department of Chemistry
Beijing Key Laboratory of Micronalytical
Methods and Instrumentation, Tsinghua University
Beijing 100084
Tel: 0086-10-62792343
E-mail: [email protected]

Received November 15, 2016; Accepted December 22, 2016; Published December 30, 2016

Citation: Yi L, Lin JM (2017) Development and Applications of Microfluidic Devices for Cell Culture in Cell Biology. Mol Biol 6:182. doi:10.4172/2168-9547.1000182

Copyright: ©2017 Yi L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Development of microfluidic culture technology combined with tissue engineering catalyzes the progress in study of cell biology. These tools will promote the understanding of physiological and pathological changes. Cancer cells and stem cells are sensitive to their surroundings, thus could be better explored by controllable microfluidic devices. In this review, we describe the ways to control cell microenvironment and explain how the influencing factors influence cellular behaviors, then present microfluidic-chip-based exemplary application for cancer models and stem cell differentiation.

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