Development and Characterization of a Novel Vesicular System for Topical Delivery: An Opportunity for Dimethylsulfoxide
Sandra Simões, Tiago Mendes, Carla Eleutério, Pedro Pinto and Andreia Ascenso*
iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal
- *Corresponding Author:
- Andreia Ascenso
iMed.ULisboa, Faculdade de Farmácia
Universidade de Lisboa, Lisbon, Portugal
E-mail: [email protected]
Received date: March 26, 2016; Accepted date: April 15, 2016; Published date: April 20, 2016
Citation: Simões S, Mendes T, Eleutério C, Pinto P, Ascenso A (2016) Development and Characterization of a Novel Vesicular System for Topical Delivery: An Opportunity for Dimethylsulfoxide. Med chem (Los Angeles) 6:250-256. doi:10.4172/2161-0444.1000354
Copyright: © 2016 Simões S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Current use of Dimethylsulfoxide (DMSO) in dermatology and in topical formulations is scarce despite its potential as a skin penetration enhancer and as a pharmacological active itself. The aim of this work is to develop and characterize a new type of semisolid formulation of Soybean Phosphatidylcholine (SPC) - DMSO deformable nanovesicles for topical application. Tretinoin is used in this work as a model substance. The formulation presents a non-newtonian pseudoplastic behaviour and a pH compatible with the skin. Stability-on-storage at different temperatures indicate an excellent physical and chemical stability and SPC-DMSO vesicles show high deformability when forced to pass through pores much smaller than their own size. These new nanovesicles show a high Tretinoin yield. Calorimetric analysis indicates a possible interaction between Tretinoin and DMSO in the lipid vesicle bilayer and vesicles formulation exhibit low cytotoxic effect below 1.25% SPC. Moreover, these vesicles once applied on the skin do not cause irritation. This study presents a new opportunity in dermal delivery for a controversial molecule such as DMSO. SPC-DMSO vesicles have plenty of advantages for topical application and future studies should confirm their superiority as drug carriers for topical application as well as for clinical evaluations in managing skin disorders.