alexa Development and Characterization Salbutamol Sulphate Mouth Disintegrating Tablet
ISSN: 2157-7048

Journal of Chemical Engineering & Process Technology
Open Access

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Research Article

Development and Characterization Salbutamol Sulphate Mouth Disintegrating Tablet

Basavaraj K Nanjwade*, Ritesh Udhani, Jatin Popat, Veerendra K Nanjwade and Sachin A Thakare
Department of Pharmaceutics, KLE University's College of Pharmacy, Belgaum-590010, Karnataka, INDIA
Corresponding Author : Dr. Basavaraj K. Nanjwade
Department of Pharmaceutics
KLE University College of Pharmacy
Belgaum-590010, Karnataka, India
Tel: 00919742431000
Fax: 00918312472387
E-mail: [email protected]
Received December 07, 2010; Accepted March 15, 2011; Published March 19, 2011
Citation: Nanjwade BK, Udhani R, Popat J, Nanjwade VK, Thakare SA (2011) Development and Characterization Salbutamol Sulphate Mouth Disintegrating Tablet. J Chem Eng Process Technol 2:105. doi:10.4172/2157-7048.1000105
Copyright: © 2011 Nanjwade BK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

An orodispersible dosage form has been developed as a user-friendly formulation that disintegrates in the mouth immediately. Thus an attempt was made to improve the onset of action of bronchodilator used commonly in the treatment of asthma. Formulation was optimized for type of disintegrant used and method of formulation. Disintegrants such as CCS (Croscarmellose Sodium), SSG (Sodium Starch Glycolate), L-HPC (Low-substituted Hydroxy Propyl Cellulose), and Crospovidone XL-10 were used and tablets were prepared by direct compression method and wet granulation. Wet granulation formulation were again sub-divided where disintegrant was added intragranularly in one type and was added both in intra and extra granulation in the other. Mint flavor was added to give good mouth feel. Out of all formulations prepared, the one prepared with Crospovidone XL-10 added both intra and extra granulation showed least disintegrating time (9 sec) with good flow property. Direct compression blends had poor flow. Tablets were also evaluated for various physicochemical parameters. All the tablets showed burst release of drug. Hence, it was concluded that out of all formulations, the one prepared with Crospovidone XL-10 added both intra and extra granulation was the best formulation as it showed the least disintegration time.

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