alexa Development and Validation of Spectrophotometric Methods for the Simultaneous Determination of Mebeverine Hydrochloride and Chlordiazepoxide in Bulk and in Dosage Form
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Development and Validation of Spectrophotometric Methods for the Simultaneous Determination of Mebeverine Hydrochloride and Chlordiazepoxide in Bulk and in Dosage Form

Othman AA1*, El-Bagary RI2, Elkady EF2 and El-Kerdawy MM3

1Medicinal Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt

2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt

3Central Administration for Pharmaceutical Affairs, Manyal, Cairo 11562, Egypt

*Corresponding Author:
Othman AA
Medicinal Chemistry Department
Faculty of Pharmacy
Mansoura University
Mansoura 35516, Egypt
Tel: +201224314304; +201000637770
E-mail: [email protected]

Received date: June 30, 2016; Accepted date: Aug 03, 2016; Published date: Aug 06, 2016

Citation: Othman AA, El-Bagary RI, Elkady EF, El-Kerdawy MM (2016) Development and Validation of Spectrophotometric Methods for the Simultaneous Determination of Mebeverine Hydrochloride and Chlordiazepoxide in Bulk and in Dosage Form. Pharm Anal Acta 7:501. doi: 10.4172/2153-2435.1000501

Copyright: © 2016 Othman AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Two accurate, precise and simple spectrophotometric methods had been developed and validated for the determination of mebeverine hydrochloride (MEB) and chlordiazepoxide (CHL). The first method was used for the determination of MEB in the range of 5-81 μg/mL and CHL in the range of 0.5-4 μg/mL, MEB was determined by second derivative spectrophotometric determination by measuring the peak amplitude at 234.8 nm (zero value of CHL) whereas CHL was determined by first derivative spectrophotometric method by measuring the peak amplitude at 280.4 nm (zero value of MEB). In the second method, three chemometric methods were evaluated for simultaneous assay of MEB and CHL. The developed methods were successfully applied to the analysis of the cited drugs in laboratory prepared mixtures and tablets with good recoveries. The validity of the proposed methods was further assessed by applying the standard addition technique. The validation was carried out following the International Conference on Harmonization (ICH) guidelines.

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