alexa Development and Validation of Stability- Indicating Tlc-Densitometric Determination of Ropinirole Hydrochloride in Bulk and Pharmaceutical Dosage Form
ISSN : 2153-2435

Pharmaceutica Analytica Acta
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Research Article

Development and Validation of Stability- Indicating Tlc-Densitometric Determination of Ropinirole Hydrochloride in Bulk and Pharmaceutical Dosage Form

SB Bari*, AR Bakhshi, PS Jain and SJ Surana

RC Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist Dhule, India

*Corresponding Author:
Dr. SB Bari
RC Patel Institute of Pharmaceutical Education and Research
Shirpur, Dist Dhule, India
Tel/fax: +91- 2563-255189
E-mail: [email protected]

Received date: June 07, 2011; Accepted date: June 22, 2011; Published date: June 24, 2011

Citation: Bari SB, Bakhshi AR, Jain PS, Surana SJ (2011) Development and Validation of Stability- Indicating Tlc-Densitometric Determination of Ropinirole Hydrochloride in Bulk and Pharmaceutical Dosage Form. Pharm Anal Acta 2:125. doi: 10.4172/2153-2435.1000125

Copyright: © 2011 Bari SB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A TLC/densitometry of ropinirole hydrochloride as a bulk drug was developed and validated.The separation was achieved on TLC aluminium plates precoated with silica gel 60F-254 as the stationary phase using chloroform: acetone: triethylamine (3.5:1.5:0.2 v/v) as mobile phase and densitometry analysis at 250 nm. The system showed compact spot for ropinirole hydrochloride (R f = 0.52 ± 0.02). The drug follows linearity in the concentration range 300 - 1800 ng per band (r 2 = 0.9983 ± 0.0008). Drug was subjected to hydrolysis, oxidation and thermal degradation which indicate the drug is susceptible to hydrolysis, oxidation and heat and degraded product did not interfere with detection and assay of ropinirole hydrochloride. Statistical analysis proves that the method is repeatable, selective and accurate for the estimation of ropinirole hydrochloride.

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