Development of 2′-Deoxy-4′-C-Ethynyl-2-Fluoroadenosine (EFdA) which has Supremely High Anti-HIV Activity and Low Toxicity and Prevents the Emergence of Resistant HIV Mutants, and Discovery of Different Substrate Selectivity between Viral and Human Nucleic Acid Polymerases
Japan Hiroshi Ohrui *
Yokohama College of Pharmacy, 601 Matanocho, Totsukaku, Yokohama, Japan Hiroshi Ohrui
- *Corresponding Author:
- Hiroshi Ohrui
Yokohama College of Pharmacy
601 Matanocho, Totsukaku
E-mail: [email protected]
Received Date: March 20, 2012; Accepted Date: April 17, 2012; Published Date: April 19, 2012
Citation: Ohrui H (2012) Development of 2'-Deoxy-4'-C-Ethynyl-2-Fluoroadenosine (EFdA) which has Supremely High Anti-HIV Activity and Low Toxicity and Prevents the Emergence of Resistant HIV Mutants, and Discovery of Different Substrate Selectivity between Viral and Human Nucleic Acid Polymerases. J Antivir Antiretrovir S10. doi: 10.4172/jaa.S10-002
Copyright: © 2012 Escobedo-Bonilla CM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The development of 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (EFdA) which has supremely high anti-HIV activity and low toxicity and prevents the emergence of resistant HIV mutants was achieved by the studies based on the author’s working hypotheses, and a very important discovery that the substrate selectivity of viral RNA-dependent nucleic acid polymerases is different from that of human DNA-dependent nucleic acid polymerases was made by these studies.