alexa Development of a Nanotechnology Based Biomedicine RISUG-M as a Female Contraceptive in India | OMICS International | Abstract
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
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Research Article

Development of a Nanotechnology Based Biomedicine RISUG-M as a Female Contraceptive in India

Rama Kant Singh*, Falgun Wanganuji Bansode, Sharad Sharma, Poonam Singh, Smrati Bhadauria, Sarika Singh and Chandishwar Nath

Divisions of Toxicology and Endocrinology, CSIR- Central Drug Research Institute, Jankipuram Extension, Lucknow-226031, India

*Corresponding Author:
Rama Kant Singh
Division of Toxicology
CSIR-CDRI, Jankipuram extension
Lucknow-226031, India
Tel: 91-9984941595
E-mail: [email protected], [email protected]

Received Date: January 09, 2015; Accepted Date: May 18, 2015; Published Date: June 02, 2015

Citation: Singh RK, Bansode FW, Sharma S, Singh P, Bhadauria S, et al. (2015) Development of a Nanotechnology Based Biomedicine RISUG-M as a Female Contraceptive in India. J Nanomed Nanotechnol 6:297. doi:10.4172/2157-7439.1000297

Copyright: © 2015 Singh RK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background and objectives: The aim of this study was to assess the toxic effect of the newly developed contraceptive RISUG-M in female Charles Foster rats.

Methods: Young, healthy and nulliporus female rats of Charles Foster strain were employed in the study. They were randomly assigned to two groups, control and treated each consisting of female animals. The contraceptive RISUG-M was injected in the fallopian tube of the treated group rats while only vehicle was injected in control group rats’ fallopian tube and observed for a period of 14 days. Initial and final body weights and food/water consumption of the animals were recorded. The haematological and biochemical parameters were analyzed. At the end of the study all the animals were sacrificed and necropsied, the organ weight was taken and their histopathological slides were prepared for microscopic examination.

Results: Body weight, food and water consumption, haematology, biochemistry, absolute and relative organ weights did not show any significant change and were well within the limit of normalcy. General health check-up, mortality, gross and microscopic examination of organs and tissues also did not reveal any sign of toxicity.

Interpretation and conclusions: From the toxicity point of view this newly developed injectable contraceptive RISUG-M does not have any adverse effect and is safe to use.

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