alexa Development of Anti-Cancer Stem Cells as Theranostic Ag
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

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Review Article

Development of Anti-Cancer Stem Cells as Theranostic Agents in the Treatment of Different Cancer Types: An Update

Arif Malik1*, Rabia Rasool1, Saima Rubab Khan1, Sulayman Waquar1, Javed Iqbal2, Syed Saeed Ul- Hassan2, Mahmood Husain Qazi3 and Aamer Qazi3

1Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Pakistan

2Faculty of Pharmacy, The University of Lahore, Pakistan

3Centre for Research in Molecular Medicine (CRiMM), The University of Lahore, Pakistan

*Corresponding Author:
Arif Malik
Institute of Molecular Biology and Biotechnology (IMBB)
The University of Lahore, Pakistan
Tel: +03218448196
E-mail: [email protected]

Received date: April 10, 2017; Accepted date: April 18, 2017; Published date: April 24, 2017

Citation: Malik A, Rasool R, Khan SR, Waquar S, Iqbal J, et al. (2017) Development of Anti-Cancer Stem Cells as Theranostic Agents in the Treatment of Different Cancer Types: An Update. J Carcinog Mutagen 8:291. doi: 10.4172/2157-2518.1000291

Copyright: © 2017 Malik A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Various unprecedented anti-tumor potential targets that robustly target cancer cells while sparing normal cells have been produced by biomedical research in cancer therapeutic intervention for interrupting disease progression and their cure. Stem cells characterize an accessible cell source for novel cell based clinical therapies by inhibiting tumor progression signalling pathways. They carry distinctive characteristics of isolation and migration to tissue inflammation site, inherited modifiability and protein expression. Stem cells are also used in immune-reconstitution and tissue regeneration. Implication of different types of stem cells as an attractive candidate for targeted delivery of anti-neoplastic agents has emerged as a promising field in anticancer therapy. Mutual interaction between cancer cells and stem cells results in effective and safer clinical therapy for tumors. Keeping in view, this review highlights the potential role of stem cells in the progression of tumor metastasis and also summarizes the role of different signaling pathways in carcinogenesis and their involvement in disease treatment. It also focuses on the current advances in stem cells practice in therapeutics of cancer.


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