alexa Development of Cytogenetic Abnormalities in Myelodysplastic Syndromes
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Development of Cytogenetic Abnormalities in Myelodysplastic Syndromes

Bandara WMMS1,2, Rathnayake AJIS1,2, Goonasekera HWW1 and Dissanayake VHW1*

1Human Genetics Unit, Faculty of Medicine, University of Colombo, Sri Lanka

2Department of Pre-clinical Sciences, Faculty of Medicine, General Sir John Kotelawala Defence University, Rathmalana, Sri Lanka

Corresponding Author:
Vajira H.W. Dissanayake
The Human Genetics Unit, Faculty of Medicine
University of Colombo, 25, Kynsey Road
Colombo 8, Sri Lanka
Tel: 0777351835
Fax: 0112691581
E-mail: [email protected]

Received date: March 08, 2016; Accepted date: May 20, 2016; Published date: May 25, 2016

Citation: Bandara WMMS, Rathnayake AJIS, Goonasekera HWW, Dissanayake VHW (2016) Development of Cytogenetic Abnormalities in Myelodysplastic Syndromes. J Mol Genet Med 10:217. doi:10.4172/1747-0862.1000217

Copyright: © 2016 Bandara WMMS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis resulting in cellular dysplasia and peripheral cytopenias. Research into MDS have found that both hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) in the nurturing niche of HSCs are genetically altered in MDS. In this review we present the existing views on the origin of cytogenetic abnormalities in HSC and MSC compartments in MDS. Based on the available data, we speculate that the origin of the chromosomal aberrations of the hematopoietic compartment occurs at the hematopoietic stem/ progenitor level. The genetic aberrations in MSC compartment appears to initiate independently from their hematopoietic counterparts. Whether the genetic events in both HSC and MSC compartments which lead to MDS occur simultaneously or at different time points in the disease development need to be determined in future.

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