alexa Development of Efflux Pumps and Inhibitors (EPIs) in A. baumanii
ISSN: 2327-5073

Clinical Microbiology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Development of Efflux Pumps and Inhibitors (EPIs) in A. baumanii

Lidan Xing, Prince Amoah Barnie, Zhaoliang Su* and Huaxi Xu*

Department of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang, PR China

*Corresponding Authors:
Xu Huaxi
Department of Immunology
Jiangsu University, Xuefu Road 301
Zhenjiang, China
Tel: +86-511-887910
Fax: 86-511-88791739
E-mail: [email protected]
 
Su Zhaoliang
Department of Immunology
Jiangsu University
Xuefu Road 301, Zhenjiang, China
Tel: +86-511-887910
Fax: 86-511-88791739
E-mail: [email protected]

Received Date: November 06, 2013; Accepted Date: December 16, 2013; Published Date: January 07, 2014

Citation: Xing L, Barnie PA, Su Z, Xu H (2014) Development of Efflux Pumps and Inhibitors (EPIs) in A. baumanii. Clin Microbial 3:135. doi: 10.4172/2327-5073.1000135

Copyright: © 2014 Xing L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Over the past three decades, Acinetobacter baumannii has emerged as an important nosocomial pathogen worldwide. Certain strains of A baumannii are now resistant to many common antimicrobial agents, including fluoroquinolone, and multidrug resistance (MDR) is often responsible for the failure of antibiotic therapy. Reasearchers have paid close attention to the emergency of MDR-AB, and PDR (pandrug-resistance)-AB, even XDR (extreme-drug resistance)-AB isolated from clinical patients, mediated primarily through the production of β-lactamases, aminoglycoside-modifying enzymes (AMEs), mutation in gene for DNA gyrase subunit A (gyrA) and DNA topoisomerase (parC), as well as efflux pumps. In this article, we discussed the roles of various efflux pumps expressed in Acinetobacter baumanii and efflux pump inhibitors (EPIs), aimed at providing an overview of the mechanism to antibiotics in Acinetobacter baumanii.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords