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ISSN: 2476-2067

Toxicology: Open Access
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Review Article

Development of International Standard on Nano Aerosol Generation for Inhalation Toxicology Study

Kangho Ahn1, David Ensor2, Monita Shama3, Michele Ostraat2, Jeremy Ramsden4, Jun Kanno5, Mahmound Ghazikhansari6, Ruben Lazos7, Mary Guumian8,Flemming R. Cassee9, Wim H. De Jong9, Kisoo Jeon10 and Il Je Yu11*

1Department of Mechanical Engineering, Hanyang University, Ansan, Korea

2RTI International, North Carolina, USA

3PETA International Science Consortium Ltd., London, UK

4University of Buckingham, Buckingham, UK

5Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Japan

6Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

7Centro National de Metrologia, Mexico

8Toxicology and Biochemistry Section National Institute for Occupational Health, University of the Witwatersrand, Johannesburg, South Africa

9National Institute for Public Health and the Environment, Bilthoven, Netherlands

10HCTm CO., LTD., Icheon, Korea

11Institute of Nano Products Safety Research, Hoseo University, Asan, Korea

*Corresponding Author:
Il Je Yu
Institute of Nanoproduct Safety Research
Hoseo University, 165 Sechul-ri
Baebang-myun, Asan 31499, Korea
Tel: 82-41-540-9630
E-mail: [email protected]

Received Date: April 26, 2017; Accepted Date: May 12, 2017; Published Date: May 17, 2017

Citation: Ahn K, Ensor D, Shama M, Ostraat M, Ramsden J, et al. (2017) Development of International Standard on Nano Aerosol Generation for Inhalation Toxicology Study. Toxicol Open Access 3:127. doi: 10.4172/2476-2067.1000127

Copyright: © 2017 Ahn K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Development ISO TR 19601 : Aerosol generation for NOAA (nano-objects and their aggregates and agglomerates) air exposure studies is completed recently. The technical report (TR) reviews methods for generating aerosols of NOAA for in vivo and in vitro inhalation studies. The goals of this technical report is to aid in selecting appropriates NOAA aerosol generator to perform a planned toxicology design. The TR describes how to approach air exposure study design after considering workplace exposure scenario with providing a flow chart to select a proper NOAA generator for aimed study. The TR presents variety of NOAA generator currently used, and describes the principles of operation, advantage at limitation of the NOAA generators. This TR will assist investigators on NOAA inhalation toxicity testing how to design inhalation exposure study with selection of proper generators. This mini-review summarizes contents of the technical report and provides the current status of science in NOAA aerosol generation.


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